HDAC inhibitor-induced drug resistance involving ATP-binding cassette transporters
文献类型：期刊论文
| 作者 | Ni, Xuan2; Li, L.1 ; Pan, Guoyu2
|
| 刊名 | ONCOLOGY LETTERS
 |
| 出版日期 | 2015-02 |
| 卷号 | 9期号:2页码:515-521 |
| 关键词 | histone deacetylase inhibitors cancer treatment multidrug resistance P-glycoprotein breast cancer resistance protein multidrug resistance protein 1/2 nuclear receptor |
| ISSN号 | 1792-1074 |
| DOI | 10.3892/ol.2014.2714 |
| 文献子类 | Review |
| 英文摘要 | Histone deacetylase (HDAC) inhibitors are becoming a novel and promising class of antineoplastic agents that have been used for cancer therapy in the clinic. Two HDAC inhibitors, vorinostat and romidepsin, have been approved by the Food and Drug Administration to treat T-cell lymphoma. Nevertheless, similar to common anticancer drugs, HDAC inhibitors have been found to induce multidrug resistance (MDR), which is an obstacle for the success of chemotherapy. The most common cause of MDR is considered to be the increased expression of adenosine triphosphate binding cassette (ABC) transporters. Numerous studies have identified that the upregulation of ABC transporters is often observed following treatment with HDAC inhibitors, particularly the increased expression of P-glycoprotein, which leads to drug efflux, reduces intracellular drug concentration and induces MDR. The present review summarizes the key ABC transporters involved in MDR following various HDAC inhibitor treatments in a range of cancer cell lines and also explored the potential mechanisms that result in MDR, including the effect of nuclear receptors, which are the upstream regulatory factors of ABC transporters. |
| WOS关键词 | HISTONE DEACETYLASE INHIBITORS ; CONSTITUTIVE ANDROSTANE RECEPTOR ; SUBEROYLANILIDE HYDROXAMIC ACID ; PROMYELOCYTIC LEUKEMIA-CELLS ; MDR1 GENE-EXPRESSION ; COLON-CANCER CELLS ; P-GLYCOPROTEIN ; MULTIDRUG-RESISTANCE ; SODIUM-BUTYRATE ; VALPROIC ACID |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000349506300001 |
| 出版者 | SPANDIDOS PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276653]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Pan, Guoyu |
| 作者单位 | 1.Ctr Drug Evaluat & Res, Ffice Clin Pharmacol, US Food & Drug Adm, Silver Spring, MD 20993 USA 2.Shanghai Inst Mat Medica, Chinese Acad Sci, Ctr Drug Safety Evaluat & Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ni, Xuan,Li, L.,Pan, Guoyu. HDAC inhibitor-induced drug resistance involving ATP-binding cassette transporters[J]. ONCOLOGY LETTERS,2015,9(2):515-521. |
| APA | Ni, Xuan,Li, L.,&Pan, Guoyu.(2015).HDAC inhibitor-induced drug resistance involving ATP-binding cassette transporters.ONCOLOGY LETTERS,9(2),515-521. |
| MLA | Ni, Xuan,et al."HDAC inhibitor-induced drug resistance involving ATP-binding cassette transporters".ONCOLOGY LETTERS 9.2(2015):515-521. |
入库方式： OAI收割
来源：上海药物研究所
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