Prediction of Enzyme's Family Based on Protein-Protein Interaction Network
文献类型：期刊论文
| 作者 | Niu, Bing1,2; Lu, Yin3; Lu, Jing3; Chen, Fuxue1; Zhao, Tonghui4; Liu, Zhanmin1; Huang, Tao5; Zhang, Yuhui6 |
| 刊名 | CURRENT BIOINFORMATICS
 |
| 出版日期 | 2015 |
| 卷号 | 10期号:1页码:16-21 |
| 关键词 | Amino acid frequency enzyme family classes jackknife test PPI network-based method |
| ISSN号 | 1574-8936 |
| DOI | 10.2174/157489361001150309122016 |
| 文献子类 | Article |
| 英文摘要 | Classification for enzymes is essential for understanding the functions of organisms because it is directly related to the knowledge about which specific target it acts on, as well as to its catalytic process. Hence, it is crucial to use an accurate and robust approach to correctly map the enzyme in specific enzyme family class that it is belong to. In this research, a protein-protein interaction (PPI) network-based method was developed for predicting the families of enzyme. As a demonstration, the overall success rate by the jackknife test in identifying enzyme's family class was 62.86%. The promising results imply that the predictor as presented in this paper may become a useful tool for studying enzymes. |
| WOS关键词 | AMINO-ACID-COMPOSITION ; SUPPORT VECTOR MACHINES ; MODIFIED MAHALANOBIS DISCRIMINANT ; FUNCTIONAL DOMAIN COMPOSITION ; SECONDARY STRUCTURE-CONTENT ; SUBCELLULAR LOCATION ; STRUCTURAL CLASS ; SUBMITOCHONDRIA LOCATIONS ; CONOTOXIN SUPERFAMILY ; FOURIER-SPECTRUM |
| 资助项目 | National Basic Research Program of China[2011CB510101] ; National Basic Research Program of China[2011CB510102] ; Innovation Program of Shanghai Municipal Education Commission[12ZZ087] ; Leading Academic Discipline Project of Shanghai Municipal Education Commission "Molecular Physiology"[00000000] ; grant of "The First-class Discipline of Universities in Shanghai"[00000000] ; Foundation for The Excellent Youth[SHU10022] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Mathematical & Computational Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000350813000005 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276750]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Huang, Tao |
| 作者单位 | 1.Shanghai Univ, Coll Life Sci, Shanghai, Peoples R China; 2.Harvard Univ, Sch Med, Schepens Eye Res Inst, Dept Ophthalmol, Boston, MA USA; 3.Shanghai Inst Mat Med, DDDC, Shanghai, Peoples R China; 4.Shanghai Univ, Shanghai Inst Biol Sci, Inst Hlth Sci, Inst Syst Biol, Shanghai, Peoples R China; 5.Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA; 6.Second Mil Med Univ, Changhai Hosp, Dept Neurosurg, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Niu, Bing,Lu, Yin,Lu, Jing,et al. Prediction of Enzyme's Family Based on Protein-Protein Interaction Network[J]. CURRENT BIOINFORMATICS,2015,10(1):16-21. |
| APA | Niu, Bing.,Lu, Yin.,Lu, Jing.,Chen, Fuxue.,Zhao, Tonghui.,...&Zhang, Yuhui.(2015).Prediction of Enzyme's Family Based on Protein-Protein Interaction Network.CURRENT BIOINFORMATICS,10(1),16-21. |
| MLA | Niu, Bing,et al."Prediction of Enzyme's Family Based on Protein-Protein Interaction Network".CURRENT BIOINFORMATICS 10.1(2015):16-21. |
入库方式： OAI收割
来源：上海药物研究所
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