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Canonical transient receptor potential 4 and its small molecule modulators

文献类型：期刊论文

作者Fu Jie1,3; Gao ZhaoBing1; Shen Bing3; Zhu, Michael X.1,2
刊名SCIENCE CHINA-LIFE SCIENCES
出版日期2015-01
卷号58期号:1页码:39-47
关键词TRPC4 channel non-selective cation channel G protein coupled receptors small molecular modulators G proteins excitation contraction Ca2+ signaling
ISSN号1674-7305
DOI10.1007/s11427-014-4772-5
文献子类Article
英文摘要Canonical transient receptor potential 4 (TRPC4) forms non-selective cation channels that contribute to phospholipase C-dependent Ca2+ entry into cells following stimulation of G protein coupled receptors and receptor tyrosine kinases. Moreover, the channels are regulated by pertussis toxin-sensitive G(i/o) proteins, lipids, and various other signaling mechanisms. TRPC4-containing channels participate in the regulation of a variety of physiological functions, including excitability of both gastrointestinal smooth muscles and brain neurons. This review is to present recent advances in the understanding of physiology and development of small molecular modulators of TRPC4 channels.
WOS关键词OPERATED CA2+ ENTRY ; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS ; NONSELECTIVE CATION CHANNELS ; ILEAL SMOOTH-MUSCLE ; TRPC CHANNELS ; CALCIUM-ENTRY ; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE ; SURFACE EXPRESSION ; INTERSTITIAL-CELLS ; ENDOTHELIAL-CELLS
资助项目National Natural Science Foundation of China[81228021] ; US National Institutes of Health[DK081654]
WOS研究方向Life Sciences & Biomedicine - Other Topics
语种英语
CSCD记录号CSCD:5386258
WOS记录号WOS:000347720800005
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/276773]  
专题神经药理学研究国际科学家工作站
通讯作者Zhu, Michael X.
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Int Scientist Workstn Neuropharmacol, Shanghai 201203, Peoples R China;
2.Univ Texas Hlth Sci Ctr Houston, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA
3.Anhui Med Univ, Dept Physiol, Hefei 230032, Peoples R China;
推荐引用方式
GB/T 7714		 Fu Jie,Gao ZhaoBing,Shen Bing,et al. Canonical transient receptor potential 4 and its small molecule modulators[J]. SCIENCE CHINA-LIFE SCIENCES,2015,58(1):39-47.
APA Fu Jie,Gao ZhaoBing,Shen Bing,&Zhu, Michael X..(2015).Canonical transient receptor potential 4 and its small molecule modulators.SCIENCE CHINA-LIFE SCIENCES,58(1),39-47.
MLA Fu Jie,et al."Canonical transient receptor potential 4 and its small molecule modulators".SCIENCE CHINA-LIFE SCIENCES 58.1(2015):39-47.

入库方式： OAI收割

来源：上海药物研究所

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