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L-Stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates heroin self-administration and cue-induced reinstatement in rats

文献类型：期刊论文

作者Yue, Kai1; Ma, Baomiao1; Chen, Lin1; Tian, Xiang1; Ru, Qin1; Gan, Yongping2; Wang, Daisong2; Jin, Guozhang1,3; Li, Chaoying1
刊名NEUROREPORT
出版日期2014-01-08
卷号25期号:1页码:7-11
关键词dopamine receptor heroin l-stepholidine relapse self-administration
ISSN号0959-4965
DOI10.1097/WNR.0000000000000012
文献子类Article
英文摘要Opiate addiction is a chronic, relapsing brain disease characterized by persistent and uncontrolled drug-seeking behavior despite negative effects. l-Stepholidine (l-SPD) is an alkaloid extract of the Chinese herb Stephania intermedia with dopamine D1 receptor partial agonistic and D2 receptor antagonistic dual actions. The unique pharmacological profile of l-SPD suggests that l-SPD may be effective for the treatment of opiate addiction. The aim of this study was to characterize the effects of l-SPD on heroin self-administration on a fixed-ratio 1 schedule and cue-induced reinstatement under an extinction/reinstatement protocol. The effect of l-SPD on the locomotor activity of heroin-free rats was also tested. We found that 2.5, 5, and 10 mg/kg of l-SPD attenuated heroin self-administration and cue-induced reinstatement without affecting locomotor activity. These results showed that l-SPD, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
WOS关键词CONDITIONED PLACE PREFERENCE ; NUCLEUS-ACCUMBENS ; COCAINE-SEEKING ; DRUG-ADDICTION ; REWARD ; ABUSE ; MECHANISMS ; MICE ; FOOD
资助项目National Natural Science Foundation of China[81302762] ; Wuhan Science and Technology Foundation[201150699189-23] ; Hubei Education Foundation[Q20123405] ; Natural Science Foundation of Hubei[2012FFB03402]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000327785400002
出版者LIPPINCOTT WILLIAMS & WILKINS
源URL[http://119.78.100.183/handle/2S10ELR8/277235]  
专题院士及顾问专家
通讯作者Li, Chaoying
作者单位1.Jianghan Univ, Wuhan Inst Biomed Sci, Wuhan 430056, Peoples R China;
2.Hubei Publ Secur Bur, Drug Prevent & Educ Ctr, Wuhan, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Yue, Kai,Ma, Baomiao,Chen, Lin,et al. L-Stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates heroin self-administration and cue-induced reinstatement in rats[J]. NEUROREPORT,2014,25(1):7-11.
APA Yue, Kai.,Ma, Baomiao.,Chen, Lin.,Tian, Xiang.,Ru, Qin.,...&Li, Chaoying.(2014).L-Stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates heroin self-administration and cue-induced reinstatement in rats.NEUROREPORT,25(1),7-11.
MLA Yue, Kai,et al."L-Stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates heroin self-administration and cue-induced reinstatement in rats".NEUROREPORT 25.1(2014):7-11.

入库方式： OAI收割

来源：上海药物研究所

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