Insights into the structure of class B GPCRs
文献类型：期刊论文
| 作者 | Hollenstein, Kaspar5; de Graaf, Chris2; Bortolato, Andrea5; Wang, Ming-Wei1,3 ; Marshall, Fiona H.5; Stevens, Raymond C.4
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| 刊名 | TRENDS IN PHARMACOLOGICAL SCIENCES
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| 出版日期 | 2014-01 |
| 卷号 | 35期号:1页码:12-22 |
| 关键词 | class B G protein-coupled receptor (GPCR) glucagon receptor (GCGR) corticotropin-releasing factor receptor 1 (CRF1) crystal structure ligand binding |
| ISSN号 | 0165-6147 |
| DOI | 10.1016/j.tips.2013.11.001 |
| 文献子类 | Review |
| 英文摘要 | The secretin-like (class B) family of G protein-coupled receptors (GPCRs) are key players in hormonal homeostasis and are interesting drug targets for the treatment of several metabolic disorders (such as type 2 diabetes, osteoporosis, and obesity) and nervous system diseases (such as migraine, anxiety, and depression). The recently solved crystal structures of the transmembrane domains of the human glucagon receptor and human corticotropin-releasing factor receptor 1 have opened up new opportunities to study the structure and function of class B GPCRs. The current review shows how these structures offer more detailed explanations to previous biochemical and pharmacological studies of class B GPCRs, and provides new insights into their interactions with ligands. |
| WOS关键词 | PROTEIN-COUPLED RECEPTORS ; CORTICOTROPIN-RELEASING-FACTOR ; 2ND TRANSMEMBRANE HELIX ; N-TERMINAL DOMAIN ; GLUCAGON RECEPTOR ; PEPTIDE-1 RECEPTOR ; LIGAND-BINDING ; AMINO-TERMINUS ; EXTRACELLULAR DOMAIN ; PARATHYROID-HORMONE |
| 资助项目 | PSI:Biology[U54 GM094618] ; Chinese Ministry of Health[2012ZX09304-011] ; Chinese Ministry of Health[2013ZX09507002] ; Shanghai Science and Technology Development Fund[11DZ2292200] ; Novo Nordisk-Chinese Academy of Sciences Research Fund[NNCAS-2011-7] ; Thousand Talents Program in China[00000000] ; European Cooperation in Science and Technology (COST) Action[CM1207] ; GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network (GLISTEN)[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000330197300003 |
| 出版者 | ELSEVIER SCIENCE LONDON |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277321]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Marshall, Fiona H. |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 2.Vrije Univ Amsterdam, Amsterdam Inst Mol Med & Syst, Fac Sci, Div Med Chem, NL-1081 HV Amsterdam, Netherlands; 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 4.Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA 5.Heptares Therapeut Ltd, Welwyn Garden City AL7 3AX, Herts, England; |
| 推荐引用方式 GB/T 7714 | Hollenstein, Kaspar,de Graaf, Chris,Bortolato, Andrea,et al. Insights into the structure of class B GPCRs[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2014,35(1):12-22. |
| APA | Hollenstein, Kaspar,de Graaf, Chris,Bortolato, Andrea,Wang, Ming-Wei,Marshall, Fiona H.,&Stevens, Raymond C..(2014).Insights into the structure of class B GPCRs.TRENDS IN PHARMACOLOGICAL SCIENCES,35(1),12-22. |
| MLA | Hollenstein, Kaspar,et al."Insights into the structure of class B GPCRs".TRENDS IN PHARMACOLOGICAL SCIENCES 35.1(2014):12-22. |
入库方式： OAI收割
来源：上海药物研究所
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