Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A
文献类型：期刊论文
| 作者 | Feng, Chenchen; Xie, Xiaofeng; Wu, Mengjun; Li, Chunzhu; Gao, Man; Liu, Mingxia; Qi, Xinming ; Ren, Jin
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| 刊名 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
 |
| 出版日期 | 2013-11 |
| 卷号 | 36期号:3页码:850-857 |
| 关键词 | Aristolochic acid Kidney injury Tanshinone I CYP1A |
| ISSN号 | 1382-6689 |
| DOI | 10.1016/j.etap.2013.07.017 |
| 文献子类 | Article |
| 英文摘要 | Hepatic CYP1A especially CYP1A2 plays an important role in the reduction of aristolochic acid I (AAI) nephrotoxicity. In this study, we investigated the effects of tanshinone I, a strong inducer of Cyp1a, on the nephrotoxicity induced by AAI. Histopathology and blood biochemistry assays showed that tanshinone I could reduce AAI-induced acute kidney injury. Pharmacokinetics analysis revealed that tanshinone I markedly decreased AUC of AAI in plasma and the content of AAI in both liver and kidney, indicating the enhancement of AAI metabolism. Real-time PCR and Western blot analysis confirmed that tanshinone I effectively increased the mRNA and protein levels of hepatic CYP1A1 and CYP1A2 in vivo. Luciferase assay showed that tanshinone I strongly increased the transcriptional activity of CYP1A1 and CYP1A2 in the similar extent. In summary, our data suggested that tanshinone I facilitated the metabolism of AAI and prevented AAI-induced kidney injury by induction of hepatic CYP1A 1/2 in vivo. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS关键词 | ARYL-HYDROCARBON RECEPTOR ; BETA-NAPHTHOFLAVONE ; UDP-GLUCURONOSYLTRANSFERASE ; P450 1A1 ; CYTOCHROME-P450 ; DETOXICATION ; BIOACTIVATION ; TRANSPORTERS ; ACTIVATION ; TOXICITY |
| 资助项目 | Key Projects of National Science and Technology Pillar Program[2012ZX09301001-006] ; Key Projects of National Science and Technology Pillar Program[2012zx09302003] |
| WOS研究方向 | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000329530600015 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277388]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Qi, Xinming |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Safety Evaluat & Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Chenchen,Xie, Xiaofeng,Wu, Mengjun,et al. Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2013,36(3):850-857. |
| APA | Feng, Chenchen.,Xie, Xiaofeng.,Wu, Mengjun.,Li, Chunzhu.,Gao, Man.,...&Ren, Jin.(2013).Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,36(3),850-857. |
| MLA | Feng, Chenchen,et al."Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 36.3(2013):850-857. |
入库方式： OAI收割
来源：上海药物研究所
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