iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery
文献类型：期刊论文
| 作者 | Zhang, Ru2; Zhang, Li-hong1; Xie, Xin1,2
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2013-06 |
| 卷号 | 34期号:6页码:765-776 |
| 关键词 | induced pluripotent stem cells (iPSCs) disease modeling drug screening toxicity evaluation cell replacement therapy small molecules drug development |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2013.21 |
| 文献子类 | Review |
| 英文摘要 | The revolutionary induced pluripotent stem cell (iPSC) technology provides a new path for cell replacement therapies and drug screening. Patient-specific iPSCs and subsequent differentiated cells manifesting disease phenotypes will finally position human disease pathology at the core of drug discovery. Cells used to test the toxic effects of drugs can also be generated from normal iPSCs and provide a much more accurate and cost-effective system than many animal models. Here, we highlight the recent progress in iPSC-based cell therapy, disease modeling and drug evaluations. In addition, we discuss the use of small molecule drugs to improve the generation of iPSCs and understand the reprogramming mechanism. It is foreseeable that the interplay between iPSC technology and small molecule compounds will push forward the applications of iPSC-based therapy and screening systems in the real world and eventually revolutionize the methods used to treat diseases. |
| WOS关键词 | PLURIPOTENT STEM-CELLS ; SOMATIC-CELLS ; SELF-RENEWAL ; NEUROLOGICAL DISEASE ; EPIGENETIC MEMORY ; HUMAN FIBROBLASTS ; GENERATION ; MOUSE ; INDUCTION ; DIFFERENTIATION |
| 资助项目 | Chinese Academy of Sciences[XDA01040301] ; Ministry of Science and Technology of China[2009CB940900] ; Ministry of Science and Technology of China[2010CB944900] ; Ministry of Science and Technology of China[2011CB965104] ; Ministry of Science and Technology of China[2011DFB30010] ; Shanghai Commission of Science and Technology[11DZ2292200] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4850353 |
| WOS记录号 | WOS:000319915000008 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277596]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Xie, Xin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Tongji Univ, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Lab Receptor Based Biomed, Shanghai 200092, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Ru,Zhang, Li-hong,Xie, Xin. iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery[J]. ACTA PHARMACOLOGICA SINICA,2013,34(6):765-776. |
| APA | Zhang, Ru,Zhang, Li-hong,&Xie, Xin.(2013).iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery.ACTA PHARMACOLOGICA SINICA,34(6),765-776. |
| MLA | Zhang, Ru,et al."iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery".ACTA PHARMACOLOGICA SINICA 34.6(2013):765-776. |
入库方式： OAI收割
来源：上海药物研究所
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