New Azalomycin F Analogs from Mangrove Streptomyces sp 211726 with Activity against Microbes and Cancer Cells
文献类型：期刊论文
| 作者 | Yuan, Ganjun1,4,5; Hong, Kui4,5; Lin, Haipeng5; She, Zhigang2; Li, Jia3
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2013-03 |
| 卷号 | 11期号:3页码:817-829 |
| 关键词 | azalomycin F Streptomyces sp 211726 cytotoxicity antimicrobial activity |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md11030817 |
| 文献子类 | Article |
| 英文摘要 | Seven new azalomycin F analogs (1-7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F-5a monoester (1), 23-valine demalonylazalomycin F-5a ester (2), 23-(6-methyl) heptanoic acid demalonylazalomycins F-3a ester (3), F-4a ester (4) and F-5a ester (5), 23-(9-methyl) decanoic acid demalonylazalomycin F-4a ester (6) and 23-(10-methyl) undecanoic acid demalony lazalomycin F-4a ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F-3a, F-4a and F-5a. Biological assays exhibited that 1-7 showed broad-spectrum antimicrobial and anti HCT-116 activities. |
| WOS关键词 | MACROCYCLIC LACTONE ANTIBIOTICS ; STRUCTURE ELUCIDATION ; HYGROSCOPICUS ; DERIVATIVES ; FLORA ; F-5A ; F-3A ; F-4A |
| 资助项目 | National High Technology Development Project (863)[2007AA09Z415] ; National High Technology Development Project (863)[2011AA09070106] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000316607800015 |
| 出版者 | MDPI AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277710]  |
| 专题 | 国家新药筛选中心 药物安全性评价中心 |
| 通讯作者 | Hong, Kui |
| 作者单位 | 1.Jiangxi Agr Univ, Coll Biosci & Engn, Nanchang 330045, Peoples R China; 2.Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China; 3.Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 4.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China; 5.Wuhan Univ, Sch Pharmaceut Sci, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan 430071, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yuan, Ganjun,Hong, Kui,Lin, Haipeng,et al. New Azalomycin F Analogs from Mangrove Streptomyces sp 211726 with Activity against Microbes and Cancer Cells[J]. MARINE DRUGS,2013,11(3):817-829. |
| APA | Yuan, Ganjun,Hong, Kui,Lin, Haipeng,She, Zhigang,&Li, Jia.(2013).New Azalomycin F Analogs from Mangrove Streptomyces sp 211726 with Activity against Microbes and Cancer Cells.MARINE DRUGS,11(3),817-829. |
| MLA | Yuan, Ganjun,et al."New Azalomycin F Analogs from Mangrove Streptomyces sp 211726 with Activity against Microbes and Cancer Cells".MARINE DRUGS 11.3(2013):817-829. |
入库方式： OAI收割
来源：上海药物研究所
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