A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats
文献类型：期刊论文
| 作者 | Cheng, Yumei1,2; Liu, Yongzhen1,2 ; Wang, Hao2; Li, Juan2; Ren, Jin1; Zhu, Liang2; Gong, Likun1
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| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2013-01-09 |
| 卷号 | 145期号:1页码:85-93 |
| 关键词 | Xian-ling-gu-bao Repeated dose toxicity No-observed-adverse-effect level |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2012.09.055 |
| 文献子类 | Article |
| 英文摘要 | Ethnopharmacological relevance: Xian-ling-gu-bao (XLGB) is a traditional Chinese prescription commonly used to treat osteoporosis, osteoarthritis, aseptic bone necrosis, climacteric syndrome, and bone fracture. However, there is limited toxicological information available on XLGB in preclinical animal model studies. It has also been recently reported that XLGB may be related to liver injury in humans. Aim of study: This study was designed to determine the potential toxic effects of XLGB, particularly hepatotoxicity, in Sprague-Dawley rats following oral administration for up to 26 weeks. Materials and methods: Male and female rats were administered XLGB by oral gavage at doses of 0, 100, 300, and 1000 mg/kg for 26 weeks followed by a recovery period of 4 weeks. Clinical signs, body weight, food consumption, ophthalmology, hematology, coagulation, serum chemistry, urinalysis, bone mineral density, hormone concentration, organ weights and histopathology were examined at the end of 13- and 26-week dosing period as well as after the recovery period. Results: Neither hepatotoxicity nor any other toxic effects were observed in the XLGB treated rats at doses up to 1000 mg/kg for 26 weeks except for a slight increase in the organ weight of the uterus in female rats at doses higher than 300 mg/kg on week 26. Conclusions: In this study, we found the no-observed-adverse-effect level (NOAEL) for XLGB in Sprague-Dawley rats was 1000 mg/kg, a dose that was equivalent to 3.3 times human dose based on body surface area. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | POSTMENOPAUSAL |
| 资助项目 | National Key Technologies RD Program[2012ZX09301001-006] ; National Key Technologies RD Program[2012ZX09302003] ; National Key Technologies RD Program[2009ZX09301-007] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000313604800011 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277769]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Zhu, Liang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Dept Pharmacol & Chem Biol, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cheng, Yumei,Liu, Yongzhen,Wang, Hao,et al. A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats[J]. JOURNAL OF ETHNOPHARMACOLOGY,2013,145(1):85-93. |
| APA | Cheng, Yumei.,Liu, Yongzhen.,Wang, Hao.,Li, Juan.,Ren, Jin.,...&Gong, Likun.(2013).A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats.JOURNAL OF ETHNOPHARMACOLOGY,145(1),85-93. |
| MLA | Cheng, Yumei,et al."A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats".JOURNAL OF ETHNOPHARMACOLOGY 145.1(2013):85-93. |
入库方式： OAI收割
来源：上海药物研究所
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