Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors
文献类型：期刊论文
| 作者 | Dai, Hou-ling2; Gao, Li-xin1; Yang, Ying2 ; Li, Jing-ya1; Cheng, Jia-gao2; Li, Jia1; Wen, Ren2; Peng, Yan-Qing2; Zheng, Jian-bin2
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2012-12-15 |
| 卷号 | 22期号:24页码:7440-7443 |
| 关键词 | Protein tyrosine phosphatase 1B Molecular docking Inhibitors Di-indolinone |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2012.10.054 |
| 文献子类 | Article |
| 英文摘要 | A series of di-indolinone derivatives was designed and synthesized to optimize our lead compounds basing on molecular docking study as PTP1B inhibitors. Successive enzymatic assay identified the synthetic di-indolinone as novel PTP1B inhibitors with low micromole-ranged inhibitory activity and at least several-fold selectivity over other tested homologous PTPs. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | INSULIN SENSITIVITY ; PTP1B INHIBITORS ; DERIVATIVES ; KINASES ; ACID ; MICE |
| 资助项目 | National Natural Science Foundation of China[21102044] ; National Natural Science Foundation of China[21172070] ; Shanghai Committee of Science and Technology[11DZ2260600] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000311425500031 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277842]  |
| 专题 | 国家新药筛选中心 药物安全性评价中心 |
| 通讯作者 | Cheng, Jia-gao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 2.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Dai, Hou-ling,Gao, Li-xin,Yang, Ying,et al. Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(24):7440-7443. |
| APA | Dai, Hou-ling.,Gao, Li-xin.,Yang, Ying.,Li, Jing-ya.,Cheng, Jia-gao.,...&Zheng, Jian-bin.(2012).Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(24),7440-7443. |
| MLA | Dai, Hou-ling,et al."Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.24(2012):7440-7443. |
入库方式： OAI收割
来源：上海药物研究所
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