Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A
文献类型：期刊论文
| 作者 | Wang, Wen-Long1,2; Chen, Hai-Jun1; Ma, Wei-Ping1; Gu, Min1 ; Fan, Min-Zhi1; Li, Jing-Ya1; Feng, Bainian2; Nan, Fa-Jun1
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2012-12 |
| 卷号 | 17期号:12页码:14522-14530 |
| 关键词 | leucamide A conformational analogues synthesis anti-influenza virus A |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules171214522 |
| 文献子类 | Article |
| 英文摘要 | In order to study the effect of heterocyclic core conformational state of leucamide A on its anti-influenza virus A activity, five conformational analogues were prepared by replacing the Pro-Leu dipeptide in the molecule with various amino acids. The amino acids used were of 2 to 6 carbons. The results showed that these replacements not only changed the conformational relationship between the 4,2-bisheterocycle tandem pair and the third heterocycle, but also had dramatic effect on its activity against influenza virus A. |
| WOS关键词 | BLEOMYCIN ; CLEAVAGE ; MOIETY ; ACIDS |
| 资助项目 | National Natural Science Foundation of China[30572242] ; Major State Hi-tech Research and Development Program[2006AA09z442] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000312608200062 |
| 出版者 | MDPI AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277857]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Feng, Bainian |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Chinese Natl Ctr Drug Screening,Shanghai Inst Mat, Shanghai 201203, Peoples R China 2.Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Wen-Long,Chen, Hai-Jun,Ma, Wei-Ping,et al. Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A[J]. MOLECULES,2012,17(12):14522-14530. |
| APA | Wang, Wen-Long.,Chen, Hai-Jun.,Ma, Wei-Ping.,Gu, Min.,Fan, Min-Zhi.,...&Nan, Fa-Jun.(2012).Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A.MOLECULES,17(12),14522-14530. |
| MLA | Wang, Wen-Long,et al."Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A".MOLECULES 17.12(2012):14522-14530. |
入库方式： OAI收割
来源：上海药物研究所
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