The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats
文献类型：期刊论文
| 作者 | Yue, Kai1; Ma, Baomiao1; Ru, Qin1; Chen, Lin1; Gan, Yongping2; Wang, Daisong2; Jin, Guozhang1,3 ; Li, Chaoying1
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| 刊名 | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
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| 出版日期 | 2012-07 |
| 卷号 | 102期号:1页码:1-5 |
| 关键词 | Dopamine Antagonist Levo-tetrahydropalmatine Self-administration Heroin Relapse |
| ISSN号 | 0091-3057 |
| DOI | 10.1016/j.pbb.2012.03.014 |
| 文献子类 | Article |
| 英文摘要 | Opiate addiction is a chronic recrudescent disorder characterized by a high rate of relapse. Levo-tetrahydropalmatine (l-THP) is an alkaloid substance extracted from Corydalis and Stephania and is contained in a number of traditional Chinese herbal preparations. Compared to other dopamine receptor antagonists, l-THP has lower affinity for D2 receptors than for D1 receptors, and a recent study showed that l-THP also binds to 03 receptors, possibly functioning as an antagonist. The unique pharmacological profile of l-THP suggests that l-THP may be effective for the treatment of opiate addiction. In this study, we investigated the effects of l-THP on heroin self-administration and reinstatement triggered by a priming injection of heroin in abstinent rats trained to stably self-administer heroin under an extinction/reinstatement protocol, and found that l-THP (2.5 and 5 mg/kg, i.p.) decreased heroin self-administration on the fixed-ratio 1 schedule and dose-dependently (1.25, 2.5 and 5 mg/kg, i.p.) inhibited heroin-induced reinstatement of heroin-seeking behavior. Importantly, l-THP (1.25 and 2.5 mg/kg, i.p.) did not affect locomotion, indicating that the observed effects of l-THP on reinstatement do not appear to be due to motor impairments. The present results demonstrated that dopamine receptor antagonist l-THP attenuates heroin self-administration and heroin-induced reinstatement. (c) 2012 Elsevier Inc. All rights reserved. |
| WOS关键词 | CONDITIONED PLACE PREFERENCE ; COCAINE SEEKING ; DRUG-ADDICTION ; RHESUS-MONKEYS ; RELAPSE ; TETRAHYDROPROTOBERBERINES ; MAINTENANCE ; ACQUISITION ; MEDICATION ; ABSTINENCE |
| 资助项目 | Wuhan Science and Technology Foundation[201150699189-23] ; Wuhan Education Foundation[2010002] |
| WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000305200600001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278034]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | Li, Chaoying |
| 作者单位 | 1.Jianghan Univ, Wuhan Inst Biomed Sci, Wuhan 430056, Peoples R China; 2.Hubei Publ Secur Bur, Drug Prevent & Educ Ctr, Wuhan 430070, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201213, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yue, Kai,Ma, Baomiao,Ru, Qin,et al. The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2012,102(1):1-5. |
| APA | Yue, Kai.,Ma, Baomiao.,Ru, Qin.,Chen, Lin.,Gan, Yongping.,...&Li, Chaoying.(2012).The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,102(1),1-5. |
| MLA | Yue, Kai,et al."The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 102.1(2012):1-5. |
入库方式： OAI收割
来源：上海药物研究所
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