Dysidavarones A-D, New Sesquiterpene Quinones from the Marine Sponge Dysidea avara
文献类型：期刊论文
| 作者 | Jiao, Wei-Hua2; Huang, Xiao-Jun1; Yang, Ji-Si2; Yang, Fan2; Piao, Shu-Jian2; Gao, Hao1; Li, Jia3 ; Ye, Wen-Cai1; Yao, Xin-Sheng1; Chen, Wan-Sheng2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2012-01-06 |
| 卷号 | 14期号:1页码:202-205 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol202994c |
| 文献子类 | Article |
| 英文摘要 | Dysidavarones A-D (1-4), four new sesquiterpene quinones possessing the unprecedented "dysidavarane" carbon skeleton, were isolated from the South China Sea sponge Dysidea avara. The structures were established by spectroscopic methods, and the absolute configurations were determined using quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum and exciton chirality CD method. Their cytotoxic activity against four human cancer cell lines and PTP1B inhibitory activity were also evaluated. |
| WOS关键词 | EFFICIENT TOTAL-SYNTHESIS ; NATURAL-PRODUCTS ; CONFIGURATION ; HYDROQUINONE ; METABOLITES |
| 资助项目 | National Natural Science Foundation of China[81072573] ; National Natural Science Foundation of China[81172978] ; National Natural Science Foundation of China[41106127] ; National Natural Science Foundation of China[81001394] ; STCSM[09dZ1975800] ; National High Technology Research and Development Program of China (863 Project)[2011AA-090701] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000298828500052 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278223]  |
| 专题 | 国家新药筛选中心 药物安全性评价中心 |
| 通讯作者 | Lin, Hou-Wen |
| 作者单位 | 1.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China; 2.Second Mil Med Univ, Changzheng Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiao, Wei-Hua,Huang, Xiao-Jun,Yang, Ji-Si,et al. Dysidavarones A-D, New Sesquiterpene Quinones from the Marine Sponge Dysidea avara[J]. ORGANIC LETTERS,2012,14(1):202-205. |
| APA | Jiao, Wei-Hua.,Huang, Xiao-Jun.,Yang, Ji-Si.,Yang, Fan.,Piao, Shu-Jian.,...&Lin, Hou-Wen.(2012).Dysidavarones A-D, New Sesquiterpene Quinones from the Marine Sponge Dysidea avara.ORGANIC LETTERS,14(1),202-205. |
| MLA | Jiao, Wei-Hua,et al."Dysidavarones A-D, New Sesquiterpene Quinones from the Marine Sponge Dysidea avara".ORGANIC LETTERS 14.1(2012):202-205. |
入库方式： OAI收割
来源：上海药物研究所
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