Differential effects of activating D1 and D2 receptors on electrophysiology of neostriatal neurons in a rat model of Parkinson's disease induced by paraquat and maneb
文献类型：期刊论文
| 作者 | Xu, Haiyan1,2; Chen, Ruirui2; Cai, Xiaoyan2; He, Defu2 |
| 刊名 | NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2011-12 |
| 卷号 | 71期号:4页码:411-420 |
| 关键词 | Neostriatum Dopamine receptors Parkinson's disease In vivo Electrophysiology |
| ISSN号 | 0168-0102 |
| DOI | 10.1016/j.neures.2011.08.011 |
| 文献子类 | Article |
| 英文摘要 | Neostriatum plays an important role in the pathophysiology of Parkinson's disease (PD). However, the changes of sensitivity of dopamine receptors of neostriatal neurons in PD have been less addressed in vivo. In the present study, systemic exposure to paraquat and maneb induced Parkinsonian symptoms and neuronal loss of substantia nigra pars compacta. Using single-unit recording methods, three types of neostriatal neurons were recorded including medium spiny-like neurons, large aspiny-like neurons and fast-spiking interneurons. In the exposed rats, increased firing activity of neostriatal neurons was revealed when compared to control rats. Following D1 receptor agonist, SKF38393 and D2 receptor agonist, LY171555 iontophoretically administrated respectively, effects of increase and decrease in firing activity were both observed in neostriatal neurons. However, stronger inhibitory effects of activating 01 receptors and weaker excitatory effects of activating D2 receptors were found in the exposed rats as compared to controls. It indicated that differential changes of sensitivity of 01 and D2 receptors in Parkinson's disease were related to the modulation of the imbalance between D1-receptor-dependent striatonigral direct pathway and D2-receptor-dependent striatopallidal indirect pathway. Our results illustrate the electrophysiological changes of in vivo neostriatal neurons in Parkinson's disease, thereby providing insight into the regulatory mechanisms of dopamine-mediated physiology. (C) 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. |
| WOS关键词 | FAST-SPIKING INTERNEURONS ; MEDIUM SPINY NEURONS ; DOPAMINE-DENERVATED STRIATUM ; BASAL GANGLIA ; PROJECTION NEURONS ; GABAERGIC INTERNEURONS ; GLOBUS-PALLIDUS ; IN-VIVO ; CHOLINERGIC INTERNEURONS ; SUBTHALAMIC NUCLEUS |
| 资助项目 | Natural Science Foundation of Shanghai[11ZR1410500] ; National Natural Science Foundation of China[20507007] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000297877000013 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278318]  |
| 专题 | 神经药理学研究国际科学家工作站 |
| 通讯作者 | He, Defu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.E China Normal Univ, Lab Neurotoxicol, Dept Environm Sci, Shanghai 200062, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Haiyan,Chen, Ruirui,Cai, Xiaoyan,et al. Differential effects of activating D1 and D2 receptors on electrophysiology of neostriatal neurons in a rat model of Parkinson's disease induced by paraquat and maneb[J]. NEUROSCIENCE RESEARCH,2011,71(4):411-420. |
| APA | Xu, Haiyan,Chen, Ruirui,Cai, Xiaoyan,&He, Defu.(2011).Differential effects of activating D1 and D2 receptors on electrophysiology of neostriatal neurons in a rat model of Parkinson's disease induced by paraquat and maneb.NEUROSCIENCE RESEARCH,71(4),411-420. |
| MLA | Xu, Haiyan,et al."Differential effects of activating D1 and D2 receptors on electrophysiology of neostriatal neurons in a rat model of Parkinson's disease induced by paraquat and maneb".NEUROSCIENCE RESEARCH 71.4(2011):411-420. |
入库方式： OAI收割
来源：上海药物研究所
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