Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle
文献类型：期刊论文
| 作者 | Chen, Xu-bing2; Zhuang, Jing-jing2; Liu, Jun-hua2; Lei, Min1 ; Ma, Lei2; Chen, Jing1; Shen, Xu1,2; Hu, Li-hong1,2
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2011-10-01 |
| 卷号 | 19期号:19页码:5776-5781 |
| 关键词 | Siraitia grosvenorii Swingle Cucurbitane triterpenoids AMPK HepG2 cell Anti-diabetic effect |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2011.08.030 |
| 文献子类 | Article |
| 英文摘要 | AMP-activated kinase (AMPK) as a key controller in the regulation of whole-body energy homeostasis, plays an important role in protecting the body from metabolic diseases. Recently, improved glucose, lipid utility and increased insulin sensitivity were observed on several diabetic rodent models treated with crude mogrosides isolated from the fruit of Siraitia grosvenorii Swingle, but the precise active compounds responsible for the anti-diabetic activity of this plant have not been clearly identified. In our current work, acid hydrolysis of crude mogrosides provided five new cucurbitane triterpenoids (1-4, 8), along with three known ones (5-7). The main aglycone mogrol (7) and compounds 4 and 8 were found to be potent AMPK activators in the HepG2 cell line. This result suggested AMPK activation by the mogroside aglycones 7 and 8 was proved to contribute at least partially to the anti-hyperglycemic and anti-lipidemic properties in vivo of S. grosvenorii. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | PROTEIN-KINASE ; BLOOD-GLUCOSE ; GLYCOSIDES ; RAT ; EXTRACT ; ALLOXAN ; MICE |
| 资助项目 | National Natural Science Foundation of China[90713046] ; National Natural Science Foundation of China[30925040] ; CAS Foundation[KSCX2-YW-R-179] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000295426400005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278386]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Chen, Jing |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xu-bing,Zhuang, Jing-jing,Liu, Jun-hua,et al. Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(19):5776-5781. |
| APA | Chen, Xu-bing.,Zhuang, Jing-jing.,Liu, Jun-hua.,Lei, Min.,Ma, Lei.,...&Hu, Li-hong.(2011).Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle.BIOORGANIC & MEDICINAL CHEMISTRY,19(19),5776-5781. |
| MLA | Chen, Xu-bing,et al."Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle".BIOORGANIC & MEDICINAL CHEMISTRY 19.19(2011):5776-5781. |
入库方式： OAI收割
来源：上海药物研究所
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