Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula
文献类型：期刊论文
| 作者 | Liu Xu1,2; Li Xiaoming1; Gao Lixin3; Cui Chuanming1,2; Li Chunshun1; Li Jia3 ; Wang Bingui1
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| 刊名 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
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| 出版日期 | 2011-05 |
| 卷号 | 29期号:3页码:686-690 |
| 关键词 | marine alga Rhodomelaceae Symphyocladia latiuscula bromophenol protein tyrosine phosphatase 1B (PTP1B) |
| ISSN号 | 0254-4059 |
| DOI | 10.1007/s00343-011-0136-1 |
| 文献子类 | Article |
| 英文摘要 | Previously, we had characterized several structurally interesting brominated phenols from the marine red alga Symphyocladia latiuscula collected from various sites. However, Phytochemical investigations on this species collected from the Weihai coastline of Shandong Province remains blank. Therefore, we characterized the chemical constituents of individuals of this species collected from the region. Eight bromophenols were isolated and identified. Using detailed spectroscopic techniques and comparisons with published data, these compounds were identified as 2,3-dibromo-4,5-dihydroxybenzyl methyl ether (1), 3,5-dibromo-4-hydroxybenzoic acid (2), 2,3,6-tribromo-4,5-dihydroxymethylbenzene (3), 2,3,6-tribromo-4,5-dihydroxybenzaldehyde (4), 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether (5), bis(2,3,6-tribromo-4,5-dihydroxyphenyl) methane (6), 1,2-bis(2,3,6-tribromo-4,5-dihydroxyphenyl)-ethane (7), and 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)-pyrrolidin-2-one (8). Among these compounds, 1 and 2 were isolated for the first time from S. latiuscula. Each compound was evaluated on the ability to inhibit protein tyrosine phosphatase 1B (PTP1B), which is a potential therapeutic target in the treatment of type 2 diabetes. Bromophenols 5, 6, and 7 showed strong activities with IC(50) values of 3.9, 4.3, and 3.5 mu mol/L, respectively. This study provides further evidence that bromophenols are predominant among the chemical constituents of Symphyocladia, and that some of these compounds may be candidates for the development of anti-diabetes drugs. |
| WOS关键词 | TYROSINE-PHOSPHATASE 1B ; 2,3,6-TRIBROMO-4,5-DIHYDROXYBENZYL METHYL-ETHER ; DISCOVERY |
| 资助项目 | National Natural Science Foundation[30530080] ; Ministry of Science and Technology of China[2007AA09Z402] ; Ministry of Science and Technology of China[2007AA09Z403] ; Department of Science and Technology of Shandong Province[2006GG2205023] |
| WOS研究方向 | Marine & Freshwater Biology ; Oceanography |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4218374 |
| WOS记录号 | WOS:000292558100024 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278534]  |
| 专题 | 国家新药筛选中心 药物安全性评价中心 |
| 通讯作者 | Wang Bingui |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China; 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Xu,Li Xiaoming,Gao Lixin,et al. Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2011,29(3):686-690. |
| APA | Liu Xu.,Li Xiaoming.,Gao Lixin.,Cui Chuanming.,Li Chunshun.,...&Wang Bingui.(2011).Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,29(3),686-690. |
| MLA | Liu Xu,et al."Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 29.3(2011):686-690. |
入库方式： OAI收割
来源：上海药物研究所
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