Isolation, purification, and immunomodulatory activity in vitro of three polysaccharides from roots of Cudrania tricuspidata
文献类型：期刊论文
| 作者 | Shi, Lei1,2; Fu, Youli1 |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2011-05 |
| 卷号 | 43期号:5页码:418-424 |
| 关键词 | Cudrania tricuspidata polysaccharide immunomodulatory activity purification |
| ISSN号 | 1672-9145 |
| DOI | 10.1093/abbs/gmr024 |
| 文献子类 | Article |
| 英文摘要 | Three water-soluble polysaccharides (CTPS-1A, CTPS-2B, and CTPS-3A) were obtained from roots of Cudrania tricuspidata (Carr.) Bur. in this study. The homogeneity of polysaccharides was determined, and the average molecular weight, ultraviolet, infrared, monosaccharide composition, and methylation analyses were carried out. Immunomodulatory activity assays in vitro showed that the three polysaccharides could directly stimulate the proliferation of mouse splenocytes alone or combining with concanavalin A or lipopolysaccharide. Furthermore, their stimulating activities were higher than that of the widely clinically used lentinan at optimal concentrations. CTPS-1A and CTPS-2B also enhanced the pinocytic activity of mouse peritoneal macrophages. |
| WOS关键词 | NEUTRAL POLYSACCHARIDE ; RETICULOENDOTHELIAL SYSTEM ; XANTHONES ; MACROPHAGES ; ACTIVATION ; SINENSIS |
| 资助项目 | National Natural Science Foundation of China[30970640] ; Qufu Normal University[XJ200822] ; Chinese Academy of Sciences[SIMM0912QN-10] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000289836200011 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278548]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Shi, Lei |
| 作者单位 | 1.Qufu Normal Univ, Coll Life Sci, Qufu 273165, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Lei,Fu, Youli. Isolation, purification, and immunomodulatory activity in vitro of three polysaccharides from roots of Cudrania tricuspidata[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2011,43(5):418-424. |
| APA | Shi, Lei,&Fu, Youli.(2011).Isolation, purification, and immunomodulatory activity in vitro of three polysaccharides from roots of Cudrania tricuspidata.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,43(5),418-424. |
| MLA | Shi, Lei,et al."Isolation, purification, and immunomodulatory activity in vitro of three polysaccharides from roots of Cudrania tricuspidata".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 43.5(2011):418-424. |
入库方式： OAI收割
来源：上海药物研究所
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