Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation
文献类型：期刊论文
| 作者 | Fan, Jun-Ting2,3; Su, Jia2,3; Peng, Yan-Min1,3; Li, Yan2; Li, Jia1 ; Zhou, Yu-Bo1; Zeng, Guang-Zhi2; Yan, He2,3; Tan, Ning-Hua2
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
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| 出版日期 | 2010-12-01 |
| 卷号 | 18期号:23页码:8226-8234 |
| 关键词 | Rubia yunnanensis Rubiyunnanins C-H Cyclopeptides Cytotoxicity Inhibition of NO production NF-kappa B pathway inhibitors |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2010.10.019 |
| 文献子类 | Article |
| 英文摘要 | Six new (rubiyunnanins C-H, 1-6) and five known (7-11) cyclic hexapeptides were isolated from the roots of Rubia yunnanensis (Franch.) Diels. The structures and stereochemistry of 1-6 were established by extensive spectroscopic analyses and chemical methods. All compounds (1-11) not only exhibited cytotoxic activities against a panel of eleven cancer cell lines with IC50 values ranging from 0.001 to 56.24 mu M, but also exerted inhibitory activities against nitric oxide (NO) production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages with IC50 values ranging from 0.05 to 12.68 mu M. Furthermore, this is the first time it is being reported that compounds 2 and 7-10 significantly inhibited TNF-alpha-induced NF-kappa B activation in HEK-293-NF-kappa B luciferase stable cells with IC50 values of 35.07, 0.03, 1.69, 12.64 and 1.18 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ANTITUMOR BICYCLIC HEXAPEPTIDES ; RA-VII ; BOUVARDIA-TERNIFOLIA ; PLANT CYCLOPEPTIDES ; PROTEIN-SYNTHESIS ; CORDIFOLIA L ; CONSTITUENTS ; RADIX ; TRITERPENOIDS ; CELLS |
| 资助项目 | National Natural Science Foundation of China[30725048] ; National Basic Research Program of China[2009 CB522300] ; Chinese Academy of Sciences[KSCX2-YW-R-177] ; Science and Technology Department of Yunnan Province[2008OC011] ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000284059500011 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278701]  |
| 专题 | 国家新药筛选中心 药物安全性评价中心 |
| 通讯作者 | Tan, Ning-Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screen, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China; 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Fan, Jun-Ting,Su, Jia,Peng, Yan-Min,et al. Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(23):8226-8234. |
| APA | Fan, Jun-Ting.,Su, Jia.,Peng, Yan-Min.,Li, Yan.,Li, Jia.,...&Tan, Ning-Hua.(2010).Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation.BIOORGANIC & MEDICINAL CHEMISTRY,18(23),8226-8234. |
| MLA | Fan, Jun-Ting,et al."Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation".BIOORGANIC & MEDICINAL CHEMISTRY 18.23(2010):8226-8234. |
入库方式： OAI收割
来源：上海药物研究所
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