Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B
文献类型：期刊论文
| 作者 | Zhang, Juan3,4 ; Shen, Qiang1; Lu, Jin-Cai4; Li, Jing-Ya1; Liu, Wen-Yong3; Yang, Jian-Jun2; Li, Jia1; Xiao, Kai3
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| 刊名 | FOOD CHEMISTRY
 |
| 出版日期 | 2010-04-15 |
| 卷号 | 119期号:4页码:1491-1496 |
| 关键词 | Cyclocarya paliurus Phenolic compounds Naphthoquinone derivative PTP1B inhibitors Anti-obesity |
| ISSN号 | 0308-8146 |
| DOI | 10.1016/j.foodchem.2009.09.031 |
| 文献子类 | Article |
| 英文摘要 | Phenolic compounds were separated from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their bioactivities were evaluated through an in vitro PTP1B inhibitory assay. Bioassay-guided fractionation of the ethanol extract has resulted in the isolation of a naphthoquinone derivative, (1R, 2R, 4R)-1,2,4-trihydroxy-1,2,3,4-tetrahydro-naphthalene-1-O-beta-D-glucopyranoside, named cyclonoside A, and a lactone, (4R, 5S, 6R)-8,9,10-trihydroxy-4-[3',4'-dihydroxyphenyl]-1,6-dioxaspiro[4,5]decan-2-one, named cyclospirolide, along with 10 known phenolic compounds: quercetin-3-O-alpha-D-glucuronide, quercetin-3-O-beta-D-glucuronide, myricetin-3-O-beta-D-glucuronide, I-caffeoylquinic acid, 3-caffeoylquinic acid, 4-caffeoylquinic acid, 5-caffeoylquinic acid, caffeic acid, 5-hydroxynaphthalene-1, 4-di-O-beta-D-glucopyranoside and piceid. The structures of these compounds were established by means of spectroscopic methods including extensive 2D NMR techniques and chemical evidence. Among all the compounds, 1, 2, 4, 5, 10 and 11 showed strong inhibition against PTP1B, with IC50 values ranging from 1.922 +/- 0.480 to 10.50 +/- 2.67 mu g/mL. The results suggested that the extract from this plant could be used as a potential source for functional food ingredient with anti-obesity. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TYROSINE-PHOSPHATASE 1B ; IN-VIVO ; OBESITY ; ACID ; MECHANISMS ; RESISTANCE ; GLYCOSIDES |
| 资助项目 | National Natural Science Foundation of China[20872179] ; National Natural Science Foundation of China[30472141] ; Science and Technology Commission of Shanghai Municipality (STCSM)[08DZ1971504] ; Shanghai-SK Development Fund[2004005-t] ; Shanghai Jiao Tong University[00000000] |
| WOS研究方向 | Chemistry ; Food Science & Technology ; Nutrition & Dietetics |
| 语种 | 英语 |
| WOS记录号 | WOS:000272989600027 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278917]  |
| 专题 | 国家新药筛选中心 药物安全性评价中心 |
| 通讯作者 | Li, Jia |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 2.Jiangxi Xiushui Shencha Co Ltd, Xiushui 332400, Jiangxi, Peoples R China 3.Second Mil Med Univ, Fac Naval Med, Lab Toxicol & Pharmacol, Shanghai 200433, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Juan,Shen, Qiang,Lu, Jin-Cai,et al. Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B[J]. FOOD CHEMISTRY,2010,119(4):1491-1496. |
| APA | Zhang, Juan.,Shen, Qiang.,Lu, Jin-Cai.,Li, Jing-Ya.,Liu, Wen-Yong.,...&Xiao, Kai.(2010).Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B.FOOD CHEMISTRY,119(4),1491-1496. |
| MLA | Zhang, Juan,et al."Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B".FOOD CHEMISTRY 119.4(2010):1491-1496. |
入库方式： OAI收割
来源：上海药物研究所
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