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Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases

文献类型：期刊论文

作者Huang, Wei Gang1; Li, Jing Ya1; Luo, Yu2; Li, Jia1; Lu, Wei2
刊名CHINESE CHEMICAL LETTERS
出版日期2009-12
卷号20期号:12页码:1461-1464
关键词Tanshinone IIA Cdc25 phosphatases Synthesis Antitumor
ISSN号1001-8417
DOI10.1016/j.cclet.2009.07.008
文献子类Article
英文摘要Two series of tanshinone IIA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors. Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line, producing IC50 values in very low micromolar range. At last, the preliminary SAR was discussed. (C) 2009 Yu Luo. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
WOS关键词HUMAN COLORECTAL-CARCINOMA ; EXPRESSION ; PROGNOSIS ; HOMOLOG ; CANCER ; MARKER ; GENE
资助项目New Century Excellent Talents in University (NCET)[00000000] ; National Natural Science Foundation of China[305722321]
WOS研究方向Chemistry
语种英语
CSCD记录号CSCD:3778171
WOS记录号WOS:000273015800018
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/279073]  
专题国家新药筛选中心
药物安全性评价中心
通讯作者Luo, Yu
作者单位1.Chinese Acad Sci, SIBS, Shanghai Inst Mat Med, Natl Ctr Drugs Screening, Shanghai 201203, Peoples R China
2.E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China;
推荐引用方式
GB/T 7714		 Huang, Wei Gang,Li, Jing Ya,Luo, Yu,et al. Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases[J]. CHINESE CHEMICAL LETTERS,2009,20(12):1461-1464.
APA Huang, Wei Gang,Li, Jing Ya,Luo, Yu,Li, Jia,&Lu, Wei.(2009).Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases.CHINESE CHEMICAL LETTERS,20(12),1461-1464.
MLA Huang, Wei Gang,et al."Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases".CHINESE CHEMICAL LETTERS 20.12(2009):1461-1464.

入库方式： OAI收割

来源：上海药物研究所

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