beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism
文献类型：期刊论文
| 作者 | Xiao, Ying1,2; Xue, Xiang1,2; Wu, Yuan-feng1,2; Xin, Guo-zheng1,2; Qian, Yong3; Xie, Tian-pei3; Gong, Li-kun1 ; Ren, Jin1
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2009-11 |
| 卷号 | 30期号:11页码:1559-1565 |
| 关键词 | aristolochic acid kidney injury beta-naphthoflavone biotransformation CYP1A |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2009.156 |
| 文献子类 | Article |
| 英文摘要 | Aim: The role of CYP1A in the protection of aristolochic acid (AA)I-induced nephrotoxicity has been suggested. In the present study we investigated the effects of beta-naphthoflavone (BNF), a non-carcinogen CYP1A inducer, on AAI-induced kidney injury. Methods: Mice were pretreated with 80 mg/kg BNF by daily intraperitoneal injection (ip) for 3 days followed by a single ip of 10 mg/kg AAI. AAI and its major metabolites in blood, liver and kidney, the expression of CYP1A1 and CYP1A2 in microsomes of liver and kidney, as well as the nephrotoxicity were evaluated. Results: BNF pretreatment prevented AAI-induced renal damage by facilitating the disposal of AAI in liver. BNF pretreatment induced the expression of CYP1A1 in both liver and kidney; but the induction of CYP1A2 was only observed in liver. Conclusion: BNF prevents AAI-induced kidney toxicity primarily through CYP1A induction. |
| WOS关键词 | BALKAN ENDEMIC NEPHROPATHY ; CHINESE HERBS NEPHROPATHY ; CYTOCHROMES P450 1A1 ; METABOLIC-ACTIVATION ; INTERSTITIAL FIBROSIS ; REDUCTIVE ACTIVATION ; UROTHELIAL CANCER ; TOXICITY ; LIVER ; 3-METHYLCHOLANTHRENE |
| 资助项目 | National Grand Fundamental Research 973 Program of China[2006CB504700] ; National Science and Technology Pillar Program[2008ZX09305-007] ; National Science and Technology Pillar Program[2009ZX09501-033] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3758774 |
| WOS记录号 | WOS:000271953500011 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279084]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Gong, Li-kun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab New Drug Res, Ctr Drug Safety & Evaluat Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China; 3.Shanghai TenGen Biomed Co Ltd, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Ying,Xue, Xiang,Wu, Yuan-feng,et al. beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism[J]. ACTA PHARMACOLOGICA SINICA,2009,30(11):1559-1565. |
| APA | Xiao, Ying.,Xue, Xiang.,Wu, Yuan-feng.,Xin, Guo-zheng.,Qian, Yong.,...&Ren, Jin.(2009).beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism.ACTA PHARMACOLOGICA SINICA,30(11),1559-1565. |
| MLA | Xiao, Ying,et al."beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism".ACTA PHARMACOLOGICA SINICA 30.11(2009):1559-1565. |
入库方式： OAI收割
来源：上海药物研究所
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