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Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent Potent Tissue-Specific Effects of Medium-Chain Fatty Acids

文献类型：期刊论文

作者Turner, Nigel2,3; Hariharan, Krit2; TidAng, Jennifer2; Frangioudakis, Georgia2; Beale, Susan M.2; Wright, Lauren E.2; Zeng, Xiao Yi2; Leslie, Simon J.2; Li, Jing-Ya2,4; Kraegen, Edward W.1,2
刊名DIABETES
出版日期2009-11
卷号58期号:11页码:2547-2554
ISSN号0012-1797
DOI10.2337/db09-0784
文献子类Article
英文摘要OBJECTIVE-Medium-chain fatty acids (MCFAs) have been reported to be less obesogenic than long-chain fatty acids (LCFAs); however, relatively little is known regarding their effect on insulin action. Here, we examined the tissue-specific effects of MCFAs on lipid metabolism and insulin action. RESEARCH DESIGN AND METHODS-C57BL6/J mice and Wistar rats were fed either a low-fat control diet or high-fat diets rich in MCFAs or LCFAs for 4-5 weeks, and markers of mitochondrial oxidative capacity, lipid levels, and insulin action were measured. RESULTS-Mice fed the MCFA diet displayed reduced adiposity and better glucose tolerance than LCFA-fed animals. In skeletal muscle, triglyceride levels were increased by the LCFA diet (77%, P < 0.01) but remained at low-fat diet control levels in the MCFA-fed animals. The LCFA diet increased (20-50%, P < 0.05) markers of mitochondrial metabolism in muscle compared with low-fat diet-fed controls; however; the increase in oxidative capacity was substantially greater in MCFA-fed animals (50-140% versus low-fat-fed controls, P < 0.01). The MCFA diet induced a greater accumulation of liver triglycerides than the LCFA diet, likely due to an upregulation of several lipogenic enzymes. In rats, isocaloric feeding of MCFA or LCFA high-fat diets induced hepatic insulin resistance to a similar degree; however, insulin action was preserved at the level of low-fat diet-fed controls in muscle and adipose from MCFA-fed animals. CONCLUSIONS-MCFAs reduce adiposity and preserve insulin action in muscle and adipose, despite inducing steatosis and insulin resistance in the liver. Dietary supplementation with MCFAs may therefore be beneficial for preventing obesity and peripheral insulin resistance. Diabetes 58:2547-2554, 2009
WOS关键词PROLIFERATOR-ACTIVATED RECEPTORS ; ENERGY-EXPENDITURE ; LONG-CHAIN ; SKELETAL-MUSCLE ; DIMINISHED DEPOSITION ; GLUCOSE-METABOLISM ; HEALTHY-MEN ; WEIGHT-LOSS ; RATS ; RESISTANCE
资助项目Diabetes Australia Research Trust[00000000] ; National Health and Medical Research Council of Australia (NHMRC)[00000000] ; University of New South Wales Postgraduate Award[00000000] ; Career Development Award[00000000]
WOS研究方向Endocrinology & Metabolism
语种英语
WOS记录号WOS:000271490900015
出版者AMER DIABETES ASSOC
源URL[http://119.78.100.183/handle/2S10ELR8/279094]  
专题国家新药筛选中心
通讯作者Turner, Nigel
作者单位1.Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
2.St Vincents Hosp, Garvan Inst Med Res, Diabet & Obes Res Program, Darlinghurst, NSW 2010, Australia;
3.Univ New S Wales, St Vincents Hosp, Sch Clin, Sydney, NSW, Australia;
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Turner, Nigel,Hariharan, Krit,TidAng, Jennifer,et al. Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent Potent Tissue-Specific Effects of Medium-Chain Fatty Acids[J]. DIABETES,2009,58(11):2547-2554.
APA Turner, Nigel.,Hariharan, Krit.,TidAng, Jennifer.,Frangioudakis, Georgia.,Beale, Susan M..,...&Ye, Ji-Ming.(2009).Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent Potent Tissue-Specific Effects of Medium-Chain Fatty Acids.DIABETES,58(11),2547-2554.
MLA Turner, Nigel,et al."Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent Potent Tissue-Specific Effects of Medium-Chain Fatty Acids".DIABETES 58.11(2009):2547-2554.

入库方式： OAI收割

来源：上海药物研究所

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