Mysterious alpha 6-containing nAChRs: function, pharmacology, and pathophysiology
文献类型：期刊论文
| 作者 | Yang, Ke-chun1,2; Jin, Guo-zhang1 ; Wu, Jie2
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2009-06 |
| 卷号 | 30期号:6页码:740-751 |
| 关键词 | alpha 6-nicotinic acetylcholine receptor dopaminergic neuron alpha-conotoxin nicotine reinforcement Parkinson's disease |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2009.63 |
| 文献子类 | Review |
| 英文摘要 | Neuronal nicotinic acetylcholine receptors (nAChRs) are the superfamily of ligand-gated ion channels and widely expressed throughout the central and peripheral nervous systems. nAChRs play crucial roles in modulating a wide range of higher cognitive functions by mediating presynaptic, postsynaptic, and extrasynaptic signaling. Thus far, nine alpha (alpha 2-alpha 10) and three beta (beta 2, beta 3, and beta 4) subunits have been identified in the CNS, and these subunits assemble to form a diversity of functional nAChRs. Although alpha 4 beta 2- and alpha 7-nAChRs are the two major functional nAChR types in the CNS, alpha 6*-nAChRs are abundantly expressed in the midbrain dopaminergic (DAergic) system, including mesocorticolimbic and nigrostriatal pathways, and particularly present in presynaptic nerve terminals. Recently, functional and pharmacological profiles of alpha 6*-nAChRs have been assessed with the use of alpha 6 subunit blockers such as alpha-conotoxin MII and PIA, and also by using alpha 6 subunit knockout mice. By modulating DA release in the nucleus accumbens (NAc) and modulating GABA release onto DAergic neurons in the ventral tegmental area (VTA), alpha 6*-nAChRs may play important roles in the mediation of nicotine reward and addiction. Furthermore, alpha 6*-nAChRs in the nigrostriatal DAergic system may be promising targets for selective preventative treatment of Parkinson's disease (PD). Thus, alpha 6*-nAChRs may hold promise for future clinical treatment of human disorders, such as nicotine addiction and PD. In this review, we mainly focus on the recent advances in the understanding of alpha 6*-nAChR function, pharmacology and pathophysiology. |
| WOS关键词 | NICOTINIC ACETYLCHOLINE-RECEPTORS ; VENTRAL TEGMENTAL AREA ; ALPHA-CONOTOXIN-MII ; PARKINSONS-DISEASE STRIATUM ; MIDBRAIN DOPAMINE NEURONS ; HIGH-CALCIUM PERMEABILITY ; BRAIN REWARD AREAS ; SUBUNIT COMPOSITION ; NIGROSTRIATAL DAMAGE ; NUCLEUS-ACCUMBENS |
| 资助项目 | Arizona Biomedical Research Commission[0028] ; Arizona Biomedical Research Commission[0057] ; Institute for Mental Health Research[00000000] ; Philip Morris International[2005-2008] ; Philip Morris International[2007-2010] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3628647 |
| WOS记录号 | WOS:000266916900010 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279217]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | Wu, Jie |
| 作者单位 | 1.Chinese Acad Sci, Dept Pharmacol, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.St Josephs Hosp, Div Neurol, Barrow Neurol Inst, Phoenix, AZ 85013 USA; |
| 推荐引用方式 GB/T 7714 | Yang, Ke-chun,Jin, Guo-zhang,Wu, Jie. Mysterious alpha 6-containing nAChRs: function, pharmacology, and pathophysiology[J]. ACTA PHARMACOLOGICA SINICA,2009,30(6):740-751. |
| APA | Yang, Ke-chun,Jin, Guo-zhang,&Wu, Jie.(2009).Mysterious alpha 6-containing nAChRs: function, pharmacology, and pathophysiology.ACTA PHARMACOLOGICA SINICA,30(6),740-751. |
| MLA | Yang, Ke-chun,et al."Mysterious alpha 6-containing nAChRs: function, pharmacology, and pathophysiology".ACTA PHARMACOLOGICA SINICA 30.6(2009):740-751. |
入库方式： OAI收割
来源：上海药物研究所
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