The Role of Tanshinone IIA in the Treatment of Obesity through Peroxisome Proliferator-Activated Receptor gamma Antagonism
文献类型：期刊论文
| 作者 | Gong, Zhenwei2; Huang, Cheng2; Sheng, Xiaoyan2; Zhang, Yuebo2; Li, Qunyi1; Wang, Ming-Wei1 ; Peng, Linling3,4; Zang, Ying Qin2
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| 刊名 | ENDOCRINOLOGY
 |
| 出版日期 | 2009-01 |
| 卷号 | 150期号:1页码:104-113 |
| ISSN号 | 0013-7227 |
| DOI | 10.1210/en.2008-0322 |
| 文献子类 | Article |
| 英文摘要 | Peroxisome proliferator-activated receptor (PPAR) gamma is a nuclear receptor that coordinates carbohydrate and lipid metabolism, and is a therapeutic target for type 2 diabetes. Tanshinone IIA ( Tan) is a lipophilic diterpene that is widely used to treat cardiovascular diseases in traditional Chinese medicine, and has recently been found to reduce body weight and lower blood lipids. However, its underlying mechanism of antiadipogenic effects remains unknown. Here, we report that Tan inhibits 3T3-L1 preadipocyte differentiation and transcriptional activities of full-length PPAR gamma and PPAR gamma ligand-binding domains. The effects of Tan are mediated through its property as a natural antagonist of PPAR gamma (dissociation constant of an inhibitor value, 2.562 +/- 0.711 mu M). Tan treatment reduced adipose mass and body weight, improved glucose tolerance, and lowered the low-density lipoprotein to high-density lipoprotein ratio without changing the food intake in a high-fat diet-induced obese animal model. Our results suggest that the combined properties of Tan in adipogenesis, glucose tolerance, lipogenesis, and cardiovascular protection are beneficial for treating diabetic patients with complex metabolic conditions, in which modulating a single target is often not sufficient to achieve the desired effect. (Endocrinology 150: 104-113, 2009) |
| WOS关键词 | DIET-INDUCED OBESITY ; PPAR-GAMMA ; SALVIA-MILTIORRHIZA ; IN-VITRO ; ADIPOCYTE DIFFERENTIATION ; INSULIN-RESISTANCE ; HEART-DISEASE ; ADIPOGENESIS ; EXPRESSION ; APOPTOSIS |
| 资助项目 | Hundred Talent Project of Chinese Academy of Sciences[00000000] ; Ministry of Science and Technology of China[2004CB518902] ; STCSM[07JC14011] |
| WOS研究方向 | Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000262052300013 |
| 出版者 | ENDOCRINE SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279365]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Zang, Ying Qin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp Affiliated, Shanghai Inst Hematol, Shanghai 200025, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, State Key Lab Med Genom, Shanghai 200025, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gong, Zhenwei,Huang, Cheng,Sheng, Xiaoyan,et al. The Role of Tanshinone IIA in the Treatment of Obesity through Peroxisome Proliferator-Activated Receptor gamma Antagonism[J]. ENDOCRINOLOGY,2009,150(1):104-113. |
| APA | Gong, Zhenwei.,Huang, Cheng.,Sheng, Xiaoyan.,Zhang, Yuebo.,Li, Qunyi.,...&Zang, Ying Qin.(2009).The Role of Tanshinone IIA in the Treatment of Obesity through Peroxisome Proliferator-Activated Receptor gamma Antagonism.ENDOCRINOLOGY,150(1),104-113. |
| MLA | Gong, Zhenwei,et al."The Role of Tanshinone IIA in the Treatment of Obesity through Peroxisome Proliferator-Activated Receptor gamma Antagonism".ENDOCRINOLOGY 150.1(2009):104-113. |
入库方式： OAI收割
来源：上海药物研究所
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