beta-C-Glycosiduronic acids and beta-C-glycosyl compounds: New PTP1B inhibitors
文献类型：期刊论文
| 作者 | Lin, Li1,3,4; Shen, Qiang2; Chen, Guo-Rong1,4; Xie, Juan3 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2008-12-15 |
| 卷号 | 18期号:24页码:6348-6351 |
| 关键词 | Protein tyrosine phosphatase 1B Inhibitor Diabetes C-Glycosyl compounds Quinone Uronic acid |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2008.10.091 |
| 文献子类 | Article |
| 英文摘要 | beta-C-Glycosiduronic acid quinones and beta-C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives (14 and 35) as well as aryl beta-C-glycosyl compounds (18, 22, 23 and 34) showed IC(50) values of 0.77-5.27 mu M against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent. (C) 2008 Elsevier Ltd. All rights reserved. |
| WOS关键词 | PROTEIN-TYROSINE PHOSPHATASES ; INSULIN SIGNAL-TRANSDUCTION ; 1B ; SENSITIVITY ; RESISTANCE ; DISCOVERY ; RECEPTOR ; LIBRARY ; OBESITY ; MICE |
| 资助项目 | Ecole Normale Superieure de Cachan[00000000] ; CNRS[00000000] ; ENS Cachan[00000000] ; National Natural Science Foundation of China[20876045] ; Shanghai Science and Technology Community[074107018] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000261141100010 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279407]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Chen, Guo-Rong |
| 作者单位 | 1.E China Univ Sci & Technol, Adv Mat Lab, Shanghai 200237, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 3.CNRS, ENS Cachan, PPSM, F-94230 Cachan, France; 4.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lin, Li,Shen, Qiang,Chen, Guo-Rong,et al. beta-C-Glycosiduronic acids and beta-C-glycosyl compounds: New PTP1B inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(24):6348-6351. |
| APA | Lin, Li,Shen, Qiang,Chen, Guo-Rong,&Xie, Juan.(2008).beta-C-Glycosiduronic acids and beta-C-glycosyl compounds: New PTP1B inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,18(24),6348-6351. |
| MLA | Lin, Li,et al."beta-C-Glycosiduronic acids and beta-C-glycosyl compounds: New PTP1B inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18.24(2008):6348-6351. |
入库方式： OAI收割
来源：上海药物研究所
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