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Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression

文献类型：期刊论文

作者Zhong, Li1,2,3; Liu, Qing1,2; Ting, Yan Sie4; Vun Yien Thien4; Kalong, Nurwafa Syafiqah Binti4; Yang, Dehua1,2; Wang, Ming-Wei1,2,3,5
刊名CHEMICAL BIOLOGY & DRUG DESIGN
出版日期2018-12
卷号92期号:6页码:1998-2008
关键词adenine derivative structural optimization thioredoxin-binding protein-2 thioredoxin-interacting protein vitamin D3-upregulated protein-1
ISSN号1747-0277
DOI10.1111/cbdd.13371
文献子类Article
英文摘要Overexpression of thioredoxin-interacting protein (TXNIP) is associated with reduced insulin sensitivity and beta-cell apoptosis. We have previously shown that W2476 inhibited high glucose-induced TXNIP expression at both mRNA and protein levels in INS-1E cells. In this study, we describe structural modification and optimization of W2476 leading to three more active derivatives, 8d, 8g, and 9h, capable of suppressing TXNIP expression in BG73 and INS-1E cells, increasing insulin production, and reducing high glucose-induced apoptosis in INS-1E cells.
WOS关键词AMYLOID POLYPEPTIDE EXPRESSION ; CARBOHYDRATE RESPONSE ELEMENT ; BETA-CELL DYSFUNCTION ; OXIDATIVE STRESS ; TXNIP ; CANCER ; GENE
资助项目Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program"of Chinese Academy of Sciences[XDA12020347] ; Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program"of Chinese Academy of Sciences[XDA12040308] ; Thousand Talents Program in China[00000000]
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000451234500009
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/279481]  
专题国家新药筛选中心
通讯作者Wang, Ming-Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China;
2.Natl Ctr Drug Screening, Shanghai, Peoples R China;
3.Univ Chinese Acad Sci, Beijing, Peoples R China;
4.Univ Malaysia Sabah, Fac Sci & Nat Resources, Kota Kinabalu, Sabah, Malaysia;
5.Fudan Univ, Sch Pharm, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Zhong, Li,Liu, Qing,Ting, Yan Sie,et al. Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2018,92(6):1998-2008.
APA Zhong, Li.,Liu, Qing.,Ting, Yan Sie.,Vun Yien Thien.,Kalong, Nurwafa Syafiqah Binti.,...&Wang, Ming-Wei.(2018).Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression.CHEMICAL BIOLOGY & DRUG DESIGN,92(6),1998-2008.
MLA Zhong, Li,et al."Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression".CHEMICAL BIOLOGY & DRUG DESIGN 92.6(2018):1998-2008.

入库方式： OAI收割

来源：上海药物研究所

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