Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
文献类型：期刊论文
| 作者 | Basnet, Rajesh1,3,5; Gong, Grace Qun1,3,4; Li, Chenyao1,3,5; Wang, Ming-Wei1,2,3,5
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| 刊名 | ACTA PHARMACEUTICA SINICA B
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| 出版日期 | 2018-09 |
| 卷号 | 8期号:5页码:767-771 |
| 关键词 | SGK AKT PI3K Cancer Signalling: Kinase Inhibitor |
| ISSN号 | 2211-3835 |
| DOI | 10.1016/j.apsh.2018.07.001 |
| 文献子类 | Article |
| 英文摘要 | The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs (particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer. (C) 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. |
| WOS关键词 | PHOSPHOINOSITIDE 3-KINASE PATHWAY ; CELL-PROLIFERATION ; BREAST-CANCER ; TUMOR-GROWTH ; INHIBITORS ; AKT ; ACTIVATION ; DOMAIN ; GLUCOCORTICOID-REGULATED-KINASE-1 ; IDENTIFICATION |
| 资助项目 | Ministry of Science and Technology of China[2014DFG32200] ; Shanghai Science and Technology Development Fund[15DZ2291600] ; Thousand Talents Program in China[[2011] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000445032400006 |
| 出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279594]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Wang, Ming-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 2.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 4.Univ Auckland, Dept Mol Med & Pathol, Auckland, New Zealand; 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Basnet, Rajesh,Gong, Grace Qun,Li, Chenyao,et al. Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention[J]. ACTA PHARMACEUTICA SINICA B,2018,8(5):767-771. |
| APA | Basnet, Rajesh,Gong, Grace Qun,Li, Chenyao,&Wang, Ming-Wei.(2018).Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention.ACTA PHARMACEUTICA SINICA B,8(5),767-771. |
| MLA | Basnet, Rajesh,et al."Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention".ACTA PHARMACEUTICA SINICA B 8.5(2018):767-771. |
入库方式： OAI收割
来源：上海药物研究所
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