Effect of Medium-chain Fatty Acid-sensing Receptor GPR84 on Glucose and Lipid Metabolism in Mice
文献类型：期刊论文
| 作者 | Fang You-Chen1,4; Zheng Yang2,3,4; Zheng Qing4; Li Jing4 ; Xie Xin4
|
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2018-08 |
| 卷号 | 45期号:8页码:853-864 |
| 关键词 | GPR84 medium-chain fatty acid-sensing receptor obesity lipid metabolism hypercholesterolemia |
| ISSN号 | 1000-3282 |
| DOI | 10.16476/j.pibb.2018.0007 |
| 文献子类 | Article |
| 英文摘要 | The global rise of obesity and obesity-associated complications such as type 2 diabetes and cardiovascular disease has become a major public health concern. The etiology and pathogenesis of these obesity related diseases are caused by multiple factors, and the free fatty acid receptors may play important roles. G protein coupled receptor 84 (GPR84) is a medium-chain (C9-C14) fatty acid-sensing receptor. However, its functions in obesity and metabolic diseases remain unclear. In this research, we established a high-fat diet induced obesity model in wild type and GPR84 knockout mice. Compared with WT mice, GPR84 knockout mice have similar levels of food intake, body weight, oral glucose tolerance test and insulin tolerance test both on normal chow diet and high-fat diet. GPR84 deficiency in mice did not affect fasting blood glucose level, insulin, triglyceride, low density lipoprotein cholesterol (LDL-c) and high density lipoprotein cholesterol (HDL-c). There were no genotypic differences in tissue mass, lipid synthesis, fatty acid oxidation and lipogenesis in mice on normal chow diet or high-fat diet. However, the concentration of total cholesterols (TC) was significantly reduced and scavenger receptor class B type I (SR-B I) was significantly increased in GPR84 knockout mice compared with WT mice on high-fat diet. These results indicate that GPR84 may not be involved in glucose and lipid metabolism in mice; instead, it may play a role in hypercholesterolemia caused by high cholesterol. |
| WOS关键词 | PROTEIN-COUPLED-RECEPTOR ; SR-BI ; GPR120 ; DISEASE ; CHOLESTEROL ; DISORDERS ; SECRETION ; PATHWAYS ; CELLS |
| 资助项目 | National Basic Research Program of China[2014CB541900] ; China National Funds for Distinguished Young Scientists[81425024] ; National Natural Science Foundation of China[81573442] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6312369 |
| WOS记录号 | WOS:000443526800007 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279638]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Xie Xin |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China; 2.ShanghaiTceh Univ, Shanghai 201210, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Fang You-Chen,Zheng Yang,Zheng Qing,et al. Effect of Medium-chain Fatty Acid-sensing Receptor GPR84 on Glucose and Lipid Metabolism in Mice[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2018,45(8):853-864. |
| APA | Fang You-Chen,Zheng Yang,Zheng Qing,Li Jing,&Xie Xin.(2018).Effect of Medium-chain Fatty Acid-sensing Receptor GPR84 on Glucose and Lipid Metabolism in Mice.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,45(8),853-864. |
| MLA | Fang You-Chen,et al."Effect of Medium-chain Fatty Acid-sensing Receptor GPR84 on Glucose and Lipid Metabolism in Mice".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 45.8(2018):853-864. |
入库方式： OAI收割
来源：上海药物研究所
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