Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy
文献类型：期刊论文
| 作者 | Yang, Jinghai1; Gao, Fei1; Han, Donglai2; Yang, Lili1; Kong, Xiangwang1; Wei, Maobin1; Cao, Jian1; Liu, Huilian1; Wu, Zhitao3; Pan, Guoyu3
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| 刊名 | MATERIALS & DESIGN
 |
| 出版日期 | 2018-02-05 |
| 卷号 | 139页码:172-180 |
| 关键词 | Zinc-based nanoplatform pH-responsive Drug delivery Multifunction |
| ISSN号 | 0264-1275 |
| DOI | 10.1016/j.matdes.2017.11.004 |
| 文献子类 | Article |
| 英文摘要 | Novel multifunctional ZnO@ (Fe3O4/ZnS:Mn2+) nanocomposites as a pH-responsive drug delivery system were designed and successfully synthesized by a self-assembling method. The as-prepared ZnO@(Fe3O4/ZnS:Mn2+) possess porous hollow structure with strong orange fluorescence and fastermagnetic response, which is beneficial for the functions of drug loading, fluorescence labeling and magnetic targeting simultaneously. Both in vitro and in vivo experiments testify that the ZnO@(Fe3O4/ZnS:Mn2+) nanocomposites own a good biocompatibility without obvious side effects on both cells and mice. After 24 days of treatment on the mice, ZnO@(Fe3O4/ZnS:Mn2+) nanocomposites greatly inhibited the tumor growth without causing both body weight change and any obvious pathological changes in major organs. The better antitumor efficacy than free DOX can be ascribed to both the accumulation of DOX-ZnO@(Fe3O4/ZnS:Mn2+) inside tumor and a sustained DOX release due to the dissociation of ZnO@(Fe3O4/ZnS:Mn2+) in acidic environment. (C) 2017 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; ZNS QUANTUM DOTS ; OXIDE NANOPARTICLE ; DOXORUBICIN ; RELEASE ; LUMINESCENCE ; NANOCARRIERS ; CANCER ; NANOCRYSTALS ; NANOSPHERES |
| 资助项目 | National Programs for High Technology Research and Development of China (863)[2013AA032202] ; National Natural Science Foundation of China[21576111] ; National Natural Science Foundation of China[61378085] ; National Natural Science Foundation of China[61605059] ; National Natural Science Foundation of China[61405072] ; Program for the development of Science and Technology of Jilin Province[20150101180JC] ; Program for the development of Science and Technology of Jilin Province[20160101287JC] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000423753200020 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279914]  |
| 专题 | 药物安全性评价中心 |
| 通讯作者 | Yang, Jinghai; Yang, Lili; Wei, Maobin |
| 作者单位 | 1.Jilin Normal Univ, Key Lab Funct Mat Phys & Chem, Minist Educ, Changchun 130013, Jilin, Peoples R China; 2.Changchun Univ Sci & Technol, Sch Mat Sci & Engn, Changchun 130022, Jilin, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Jinghai,Gao, Fei,Han, Donglai,et al. Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy[J]. MATERIALS & DESIGN,2018,139:172-180. |
| APA | Yang, Jinghai.,Gao, Fei.,Han, Donglai.,Yang, Lili.,Kong, Xiangwang.,...&Pan, Guoyu.(2018).Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy.MATERIALS & DESIGN,139,172-180. |
| MLA | Yang, Jinghai,et al."Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy".MATERIALS & DESIGN 139(2018):172-180. |
入库方式： OAI收割
来源：上海药物研究所
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