Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy
文献类型:期刊论文
作者 | Rahman Wan Nordiana; Bishara Nour; Ackerly Trevor; He Cheng Fa![]() |
刊名 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
![]() |
出版日期 | 2009 |
卷号 | 5期号:2页码:136-142 |
关键词 | Gold Nanoparticles Superficial Radiation Therapy Dose Enhancement Factor |
ISSN号 | 1549-9634 |
DOI | 10.1016/j.nano.2009.01.014 |
英文摘要 | Iodinated contrast agents, which are routinely used to improve contrast in x-ray diagnostic radiography, have been successfully proven to enhance radiation effects in kilovoltage x-ray radiation therapy beams. The studies determined the influence of iodine on the level of radiation biotoxicity to cells as an indicator of the radiation dose enhancement. The use of other high-atomic-number materials such as gold nanoparticles (AuNPs) may also provide advantages in terms of radiation dose enhancement. In this work AuNPs have been used for the enhancement of radiation effects on bovine aortic endothelial cells of superficial x-ray radiation therapy and megavoltage electron radiation therapy beams. Results reveal an increase of cell damage with increasing concentration of AuNPs. At 1 mM concentration of AuNPs, enhancement of radiation peaked at 25 times for a kilovoltage x-ray beam. AuNPs showed similar effects on electron beams but to a lesser extent. This study showed that AuNPs can be used to enhance the effect of radiation doses from kilovoltage x-ray radiation therapy and megavoltage electron radiation therapy beams. In the prevailing clinical circumstances, wherein radiation therapy dose is constrained by normal tissue tolerance, this enhancement could in the future be used to improve local control in superficial x-ray treatments, megavoltage electron beam radiation therapy, microbeam radiation therapy, and intraoperative irradiation using kilovoltage x-rays or megavoltage electron beams. Moreover, the value of this work also stems from the fact that the damage to the endothelial cells lining the highly vasculature structure of tumors deprives tumors of their oxygen and nutrients supply and enhances the efficiency of radiation therapy treatment, where it has been proven that more of the AuNPs injected into animals ends up into the blood than in the tumor. |
学科主题 | Science & Technology - Other Topics ; Research & Experimental Medicine |
WOS记录号 | WOS:000267418000005 |
公开日期 | 2012-11-29 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/1835] ![]() |
专题 | 新疆理化技术研究所_材料物理与化学研究室 固体辐射物理研究室 |
作者单位 | RMIT Univ, Sch Med Sci, Med Radiat Discipline, Bundoora, Vic, Australia;Alfred Hosp, William Buckland Radiotherapy Ctr, Prahran, Vic 3181, Australia;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi, Xinjiang, Peoples R China |
推荐引用方式 GB/T 7714 | Rahman Wan Nordiana,Bishara Nour,Ackerly Trevor,et al. Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2009,5(2):136-142. |
APA | Rahman Wan Nordiana.,Bishara Nour.,Ackerly Trevor.,He Cheng Fa.,Jackson Price.,...&Geso Moshi.(2009).Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,5(2),136-142. |
MLA | Rahman Wan Nordiana,et al."Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 5.2(2009):136-142. |
入库方式: OAI收割
来源:新疆理化技术研究所
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。