Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem
文献类型：期刊论文
| 作者 | Jing, Bolin1,2; Cheng, Gong1; Li, Jianjun1; Wang, Zhuo A.1; Du, Yuguang1 |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2019-07-01 |
| 卷号 | 17期号:7页码:13 |
| 关键词 | partially acetylated chitooligosaccharides liver tumor cell metastasis dynamic tumor-vessel microsystem |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md17070415 |
| 英文摘要 | Chitooligosaccharides (COS), the only cationic oligosaccharide in nature, have been demonstrated to have anti-tumor activity. However, the inhibitory effects of COS on different stages of tumor metastasis are still unknown, and it is not clear what stage(s) of tumor metastasis COS targeted. To study the inhibitory effects of a new partially acetylated chitooligosaccharide (paCOS) with fraction of acetylation (F-A) 0.46 on each phase of liver cancer cell metastasis, a dynamic tumor-vessel microsystem undergoing physiological flow was leveraged. paCOS (F-A = 0.46) significantly inhibited proliferation of HepG2 cells through vascular absorption on the chip, and inhibited migration of HepG2 cells by inhibiting the formation of pseudopod in liver tumor cells. It was also found that paCOS at 10 mu g/mL had a stronger inhibitory effect on liver tumor cells invading blood vessels than that of paCOS at 100 mu g/mL, and paCOS at 100 mu g/mL, which had a significant destructive effect on tumor vascular growth and barrier function. Moreover, paCOS reduced the number of liver tumor cells adhering onto the surface of HUVECs layer after 3 h of treatment. Therefore, the results revealed that paCOS had considerable potential as drugs for anti-tumor metastasis. |
| WOS关键词 | HEXA-N-ACETYLCHITOHEXAOSE ; CANCER STATISTICS ; D-GLUCOSAMINE ; IN-VITRO ; CHITOOLIGOSACCHARIDES ; MICROENVIRONMENT ; DEACETYLATION ; ACTIVATION ; GROWTH ; MODEL |
| 资助项目 | National Natural Science Foundation of China[31870802] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000478650600001 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/30356]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Li, Jianjun; Wang, Zhuo A.; Du, Yuguang |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jing, Bolin,Cheng, Gong,Li, Jianjun,et al. Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem[J]. MARINE DRUGS,2019,17(7):13. |
| APA | Jing, Bolin,Cheng, Gong,Li, Jianjun,Wang, Zhuo A.,&Du, Yuguang.(2019).Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem.MARINE DRUGS,17(7),13. |
| MLA | Jing, Bolin,et al."Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem".MARINE DRUGS 17.7(2019):13. |
入库方式： OAI收割
来源：过程工程研究所
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