中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 过程工程研究所
  3. 中国科学院过程工程研究所
Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy

文献类型：期刊论文

作者Mei, Enci1,2; Li, Shukun1,3; Song, Jingwen1,2,3; Xing, Ruirui1; Li, Zhiming2; Yan, Xuehai1,3
刊名COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
出版日期2019-09-20
卷号577页码:570-575
关键词Self-assembly Collagen Alginate Injectable hydrogel Tumor therapy
ISSN号0927-7757
DOI10.1016/j.colsurfa.2019.06.023
英文摘要Combination therapy, integrating multiple merits of monotherapy into one platform for enhanced antitumor efficacy while eliminating the likelihoods of tumor recurrence and metastasis, is of particular interest in clinical application. Hydrogels self-assembled by biologically-based building blocks can be used as promising platforms for incorporation of one or more therapeutic drugs to gain additive or synergistic therapeutic functions. Herein, antitumor combination therapy based on injectable collagen/alginate hydrogels is achieved by simultaneous encapsulation of the photothermal drug methylene blue (MB) and immunological agent imiquimod (R837). The resulting hybrid hydrogel (Gel-MB-R837) with shear-thinning and self-healing properties is applicable for localized delivery and prolonged release of therapeutic drugs. The antitumor efficacy can be significantly enhanced by combinatorial photothermal therapy (PTT) and immunotherapy treatments through the synergy of MB and R837. Moreover, the initial PTT not only eradicates primary tumors, but also generates tumor-associated antigens (TAA), which combines with R837 to trigger immune response for further inhibiting tumor recurrence and metastasis. Therefore, the biocompatible hybrid hydrogels starting from naturally-occurring biomacromolecules offer promising prospects for combinatorial photothermal and immuno tumor therapy.
WOS关键词DRUG-DELIVERY ; PHOTODYNAMIC THERAPY ; PEPTIDE ; COLLAGEN ; NANOPARTICLES ; PROTEIN ; TRANSFORMATION ; NANODRUGS ; NANOCAGES ; SYSTEMS
资助项目National Natural Science Foundation of China[21802144] ; National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000477008000065
出版者ELSEVIER
资助机构National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
源URL[http://ir.ipe.ac.cn/handle/122111/30503]  
专题中国科学院过程工程研究所
通讯作者Xing, Ruirui; Li, Zhiming; Yan, Xuehai
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Wenzhou Med Univ, Dept Dermatol & Venereol, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Mei, Enci,Li, Shukun,Song, Jingwen,et al. Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2019,577:570-575.
APA Mei, Enci,Li, Shukun,Song, Jingwen,Xing, Ruirui,Li, Zhiming,&Yan, Xuehai.(2019).Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,577,570-575.
MLA Mei, Enci,et al."Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 577(2019):570-575.

入库方式： OAI收割

来源：过程工程研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。