Synthesis of Ultrathin Biotite Nanosheets as an Intelligent Theranostic Platform for Combination Cancer Therapy
文献类型：期刊论文
| 作者 | Ji, Xiaoyuan2,3,4,5; Kang, Yong6; Ouyang, Jiang5; Chen, Yunhan5; Artzi, Dolev5; Zeng, Xiaobin1,2,3; Xiao, Yuling5; Feng, Chan5; Qi, Baowen5; Kim, Na Yoon5 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2019-08-20 |
| 页码 | 10 |
| 关键词 | 2D nanosheets biotite combination cancer therapy reactive oxygen species |
| DOI | 10.1002/advs.201901211 |
| 英文摘要 | Biotite, also called black mica (BM), is a group of sheet silicate minerals with great potential in various fields. However, synthesis of high-quality BM nanosheets (NSs) remains a huge challenge. Here, an exfoliation approach is provided that combines calcination, n-butyllithium exchange and intercalation, and liquid exfoliating processes for the high-yield synthesis of ultrathin BM NSs. Due to the presence of MgO, Fe2O3, and FeO in these NSs, PEGylated BM can be engineered as an intelligent theranostic platform with the following unique features: i) Fe3+ can damage the tumor microenvironment (TME) through glutathione consumption and O-2 production; ii) Generated O-2 can be further catalyzed by MgO with oxygen vacancy to generate O-2(-); iii) The Fe2+-catalyzed Fenton reaction can produce OH by disproportionation reactions of H2O2 in the TME; iv) Reactions in (i) and (iii) circularly regenerate Fe2+ and Fe3+ for continuous consumption of glutathione and H2O2 and constant production of OH and O-2; v) The NSs can be triggered by a 650 nm laser to generate O-2(-) from O-2 as well as by an 808 nm laser to generate local hyperthermia; and vi) The fluorescent, photoacoustic, and photothermal imaging capabilities of the engineered NSs allow for multimodal imaging-guided breast cancer treatment. |
| WOS关键词 | 2-DIMENSIONAL NANOMATERIALS ; PHOTODYNAMIC THERAPY ; MUSCOVITE ; SEMICONDUCTOR ; EXCHANGE ; PROBES ; DOTS ; MICA |
| 资助项目 | U.S. METAvivor Early Career Investigator Award[2018A020560] ; Harvard Medical School (HMS)/Brigham and Women's Hospital (BWH) Department of Anesthesiology-Basic Scientist Grant[2420 BPA075] ; National Natural Science Foundation of China[81801826] ; Science, Technology & Innovation Commission of Shenzhen Municipality[JCYJ20180307153300735] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000481803200001 |
| 出版者 | WILEY |
| 资助机构 | U.S. METAvivor Early Career Investigator Award ; Harvard Medical School (HMS)/Brigham and Women's Hospital (BWH) Department of Anesthesiology-Basic Scientist Grant ; National Natural Science Foundation of China ; Science, Technology & Innovation Commission of Shenzhen Municipality |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/30585]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zeng, Xiaobin; Farokhzad, Omid C.; Tao, Wei |
| 作者单位 | 1.Shenzhen Univ, Sch Med, Guangdong Prov Key Lab Reg Immun & Dis, Shenzhen 518061, Peoples R China 2.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Infect Dis, Shenzhen 518120, Guangdong, Peoples R China 3.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Ctr Lab,Longhua Branch, Shenzhen 518120, Guangdong, Peoples R China 4.Jinan Univ, Postdoctoral Res Stn, Integrated Chinese & Western Med, Guangzhou 510632, Guangdong, Peoples R China 5.Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA 6.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Xiaoyuan,Kang, Yong,Ouyang, Jiang,et al. Synthesis of Ultrathin Biotite Nanosheets as an Intelligent Theranostic Platform for Combination Cancer Therapy[J]. ADVANCED SCIENCE,2019:10. |
| APA | Ji, Xiaoyuan.,Kang, Yong.,Ouyang, Jiang.,Chen, Yunhan.,Artzi, Dolev.,...&Tao, Wei.(2019).Synthesis of Ultrathin Biotite Nanosheets as an Intelligent Theranostic Platform for Combination Cancer Therapy.ADVANCED SCIENCE,10. |
| MLA | Ji, Xiaoyuan,et al."Synthesis of Ultrathin Biotite Nanosheets as an Intelligent Theranostic Platform for Combination Cancer Therapy".ADVANCED SCIENCE (2019):10. |
入库方式： OAI收割
来源：过程工程研究所
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