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Spatiotemporally Coupled Photoactivity of Phthalocyanine-Peptide Conjugate Self-Assemblies for Adaptive Tumor Theranostics

文献类型：期刊论文

作者Li, Shukun2,3; Zhao, Luyang2; Chang, Rui2,3; Xing, Ruirui2; Yan, Xuehai1,2,3
刊名CHEMISTRY-A EUROPEAN JOURNAL
出版日期2019-09-13
页码7
关键词peptides phthalocyanines self-assembly spatiotemporal photoactivity tumor theranostics
ISSN号0947-6539
DOI10.1002/chem.201903322
英文摘要Spatiotemporally coupled tumor phototheranostic platforms offer a flexible and precise system that takes the biological interaction between tumors and photoactive agents into consideration for optimizing treatment, which is highly consistent with precision medicine. However, the fabrication of monocomponent-based photoactive agents applicable to multifold imaging techniques and multiple therapies in a facile way remains challenging. In this study, we developed simple phthalocyanine-peptide (PF) conjugate-based monocomponent nanoparticles with spatiotemporally coupled photoactivity for adaptive tumor theranostics. The self-assembled PF nanoparticles possess well-defined spherical nanostructures and excellent colloidal stability along with supramolecular photothermal effects. Importantly, the PF nanoparticles showed switchable photoactivity triggered by their interactions with the cell membrane, which enables an adaptive transformation from photothermal therapy (PTT) and photoacoustic imaging (PAI) to photodynamic therapy (PDT) and corresponding fluorescence imaging (FI). Theranostic modalities are integrated in a spatiotemporally coupled manner, providing a facile, biocompatible and effective route for localized tumor phototherapy. This study offers a flexible and versatile strategy to integrate multiple theranostic modalities into a single component so that it can realize its full potential and thereby amplify its therapeutic efficacy, creating promising opportunities for the design of theranostics and further highlighting their clinical prospects to the diagnosis and treatment of cancers.
WOS关键词NANOPARTICLES ; THERAPY
资助项目National Natural Science Foundation of China[51861145304] ; National Natural Science Foundation of China[21703252] ; National Natural Science Foundation of China[21802144] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2017VEA0023]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000486442100001
出版者WILEY-V C H VERLAG GMBH
资助机构National Natural Science Foundation of China ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative
源URL[http://ir.ipe.ac.cn/handle/122111/31052]  
专题中国科学院过程工程研究所
通讯作者Yan, Xuehai
作者单位1.Chinese Acad Sci, Ctr Mesosci, Inst Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Li, Shukun,Zhao, Luyang,Chang, Rui,et al. Spatiotemporally Coupled Photoactivity of Phthalocyanine-Peptide Conjugate Self-Assemblies for Adaptive Tumor Theranostics[J]. CHEMISTRY-A EUROPEAN JOURNAL,2019:7.
APA Li, Shukun,Zhao, Luyang,Chang, Rui,Xing, Ruirui,&Yan, Xuehai.(2019).Spatiotemporally Coupled Photoactivity of Phthalocyanine-Peptide Conjugate Self-Assemblies for Adaptive Tumor Theranostics.CHEMISTRY-A EUROPEAN JOURNAL,7.
MLA Li, Shukun,et al."Spatiotemporally Coupled Photoactivity of Phthalocyanine-Peptide Conjugate Self-Assemblies for Adaptive Tumor Theranostics".CHEMISTRY-A EUROPEAN JOURNAL (2019):7.

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来源：过程工程研究所

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