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Highly Efficient In Vivo Cancer Therapy by an Implantable Magnet Triboelectric Nanogenerator

文献类型：期刊论文

作者Zhao, Chaochao2,3; Feng, Hongqing2,3; Zhang, Lijun4; Li, Zhe2,3; Zou, Yang2; Tan, Puchuan2,3; Ouyang, Han2,3; Jiang, Dongjie2,3; Yu, Min2,3; Wang, Chan2,3
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2019-10-01
卷号29期号:41页码:11
ISSN号1616-301X
关键词cancer therapy drug delivery enhanced permeability and retention (EPR) effect nanogenerator red blood cells (RBCs)
DOI10.1002/adfm.201808640
英文摘要In this work, a nanogenerator-controlled drug delivery system (DDS) for use in cancer therapy is successfully established. A new magnet triboelectric nanogenerator (MTENG) is fabricated that can guarantee the contact and detach cycle between the two friction layers and effectively increase the TENG output, up to 70 V after implantation. Using a special structural design, without the commonly used spacer, this contacting-mode MTENG can ensure a high and consistent electricity output after encapsulation and implantation. Doxorubicin-(DOX-) loaded red blood cells (RBCs) are employed as the anti-tumor DDS in this study. After DOX loading, the RBC membranes are stable and the self-release is very slow. However, upon electric stimulation from the MTENG, the release of DOX is remarkably increased, and falls back to normal again after the stimulation. Thus a controllable DDS is established. The MTENG-controllable DDS achieves an outstanding killing of carcinomatous cells both in vitro and in vivo at a low DOX dosage. These results demonstrate a prominent therapeutic effect of the MTENG-controlled DDS for cancer therapy, which is highly promising for application in the clinic.
WOS关键词PEGYLATED LIPOSOMAL DOXORUBICIN ; SQUAMOUS-CELL CARCINOMA ; PHASE-II ; DELIVERY ; NANOPARTICLES ; PERFORMANCE ; STRATEGIES ; CHEMORADIOTHERAPY ; CHEMOTHERAPY ; COMBINATION
资助项目National Key R&D Project from the Ministry of Science and Technology, China[2016YFA0202703] ; National Key R&D Project from the Ministry of Science and Technology, China[2017YFA0207900] ; National Natural Science Foundation of China[61875015] ; National Natural Science Foundation of China[31571006] ; National Natural Science Foundation of China[81601629] ; National Natural Science Foundation of China[21801019] ; Beijing Talents Fund[2015000021223ZK21] ; Beijing Natural Science Foundation[2182091] ; National Youth Talent Support Program
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000489051200017
资助机构National Key R&D Project from the Ministry of Science and Technology, China ; National Natural Science Foundation of China ; Beijing Talents Fund ; Beijing Natural Science Foundation ; National Youth Talent Support Program
源URL[http://ir.ipe.ac.cn/handle/122111/31157]  
专题中国科学院过程工程研究所
通讯作者Wei, Wei; Li, Zhou
作者单位1.Guangxi Univ, Sch Phys Sci & Technol, Ctr Nanoenergy Res, Nanning 530004, Peoples R China
2.Chinese Acad Sci, Beijing Key Lab Micronano Energy & Sensor, Beijing Inst Nanoenergy & Nanosyst, CAS Ctr Excellence Nanosci, Beijing 100083, Peoples R China
3.Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Chaochao,Feng, Hongqing,Zhang, Lijun,et al. Highly Efficient In Vivo Cancer Therapy by an Implantable Magnet Triboelectric Nanogenerator[J]. ADVANCED FUNCTIONAL MATERIALS,2019,29(41):11.
APA Zhao, Chaochao.,Feng, Hongqing.,Zhang, Lijun.,Li, Zhe.,Zou, Yang.,...&Li, Zhou.(2019).Highly Efficient In Vivo Cancer Therapy by an Implantable Magnet Triboelectric Nanogenerator.ADVANCED FUNCTIONAL MATERIALS,29(41),11.
MLA Zhao, Chaochao,et al."Highly Efficient In Vivo Cancer Therapy by an Implantable Magnet Triboelectric Nanogenerator".ADVANCED FUNCTIONAL MATERIALS 29.41(2019):11.

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来源：过程工程研究所

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