The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice
文献类型：期刊论文
| 作者 | Xie, Yuanyuan3,4,5; Li, Wenjun3,5; Lu, Chenyang1; Zhu, Limeng2; Qin, Song3,5; Du, Zhenning4 |
| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2019-10-01 |
| 卷号 | 103期号:20页码:8559-8569 |
| 关键词 | Phycocyanin Pulmonary fibrosis Cytokines Intestinal microbiome |
| ISSN号 | 0175-7598 |
| DOI | 10.1007/s00253-019-10018-7 |
| 英文摘要 | Phycocyanin (PC) is a light-harvesting protein isolated from Spirulina and has health benefits for a range of diseases including pulmonary fibrosis (PF). In this study, a bleomycin-induced pulmonary fibrosis model was used to determine whether PC attenuates PF and modulates the intestinal microbiota. The results showed that PC intervention attenuated the pulmonary fibrosis, demonstrated by hematoxylin-eosin staining (HE), Masson's trichrome staining, and lung dry-wet weight ratio, and PC significantly inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and lipopolysaccharide (LPS). Additionally, intestinal microbiota analysis revealed that PC intervention significantly increased the bacterial diversity and richness. Correlation analysis indicated that 9 families and 17 genes were significantly associated with at least 1 physiological index. And PC intervention significantly decreased the bacteria which is related to inflammation and dramatically increased the SCFAs-producing bacteria and probiotics. These data indicated that PC can decrease the pro-inflammatory cytokines and regulate the intestinal microbiota in BLM-induced PF mice. |
| WOS关键词 | C-PHYCOCYANIN ; HELICOBACTER-PYLORI ; ANTIOXIDANT ; SPIRULINA |
| 资助项目 | National Key Research and Development Program of China[2018YFD0901102] ; Key Research and Development Program of Yantai[2019XDHZ101] |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000491439700024 |
| 出版者 | SPRINGER |
| 资助机构 | National Key Research and Development Program of China ; Key Research and Development Program of Yantai |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/31208]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Qin, Song; Du, Zhenning |
| 作者单位 | 1.Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China 4.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China 5.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Yuanyuan,Li, Wenjun,Lu, Chenyang,et al. The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2019,103(20):8559-8569. |
| APA | Xie, Yuanyuan,Li, Wenjun,Lu, Chenyang,Zhu, Limeng,Qin, Song,&Du, Zhenning.(2019).The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,103(20),8559-8569. |
| MLA | Xie, Yuanyuan,et al."The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 103.20(2019):8559-8569. |
入库方式： OAI收割
来源：过程工程研究所
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