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Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment

文献类型：期刊论文

作者Liu, Linying1,2; Li, Yan2; Liu, Ruiyuan1,2; Shen, Qi2; Li, Yanhui2; Shi, Zhuyan1,2; Shen, Jie1,2; Ji, Weihong1,2; Zhang, Xin2
刊名MATERIALS HORIZONS
出版日期2019-11-01
卷号6期号:9页码:1923-1929
ISSN号2051-6347
DOI10.1039/c9mh00482c
英文摘要We present a facile approach of a switchable polymer-gold nanoparticle, which programmatically co-delivers genes and chemical drugs (gene-chem). Between the delivery pathway and specific diseased cells the nanoparticle is switchable and allows for enhanced computed tomography (CT) imaging and synergistic neuronal recovery. The delivery system with precise conversion will serve as a powerful gene-chem co-delivery platform to enable accurate brain disease therapy.
WOS关键词PARKINSONS-DISEASE ; BRAIN ; DOPAMINE ; MECHANISMS ; CLEARANCE ; DISCOVERY ; THERAPY ; STEM ; RNA
资助项目Beijing Municipal Science & Technology Commission[Z161100002616015] ; National High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] ; National Natural Science Foundation of China[31522023] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[51573188]
WOS研究方向Chemistry ; Materials Science
语种英语
WOS记录号WOS:000490535600014
出版者ROYAL SOC CHEMISTRY
资助机构Beijing Municipal Science & Technology Commission ; National High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China
源URL[http://ir.ipe.ac.cn/handle/122111/31224]  
专题中国科学院过程工程研究所
通讯作者Zhang, Xin
作者单位1.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Linying,Li, Yan,Liu, Ruiyuan,et al. Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment[J]. MATERIALS HORIZONS,2019,6(9):1923-1929.
APA Liu, Linying.,Li, Yan.,Liu, Ruiyuan.,Shen, Qi.,Li, Yanhui.,...&Zhang, Xin.(2019).Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment.MATERIALS HORIZONS,6(9),1923-1929.
MLA Liu, Linying,et al."Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment".MATERIALS HORIZONS 6.9(2019):1923-1929.

入库方式： OAI收割

来源：过程工程研究所

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