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Ultrasonic Assisted Extraction of Artemisinin from Artemisia annua L. Using Poly(Ethylene Glycol): Toward a Greener Process

文献类型：期刊论文

作者Prawang, Phongphat1,2; Zhang, Yongqiang1,2; Zhang, Ying1; Wang, Hui1,2
刊名INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
出版日期2019-10-02
卷号58期号:2页码:18320-18328
ISSN号0888-5885
DOI10.1021/acs.iecr.9b03305
英文摘要Poly(ethylene glycol) (PEG), a kind of "green" medium, was used to extract artemisinin from the Chinese herb Artemisia annua L. to replace the traditional volatile and explosive solvents like petroleum ether, diethyl ether, etc. PEGs, with different molecular weights, show excellent ability for artemisinin extraction, and the extraction efficiency decreased with the increase of molecular weight. It was also demonstrated that ultrasonic irradiation could further enhance extraction efficiency compared with conventional water bath heating. Results indicate that the extraction amount of artemisinin from one gram of the leaves could reach 15.8 mg/g under the optimal conditions with ultrasonic power of 100 W, the temperature of 50 degrees C, time of 1 h in PEG-200, which were optimized by response surface method. Compared with Soxhlet extraction using petroleum ether (PE), the method developed here shows higher extraction efficiency (15.8 mg/g for PEG vs. 14.9 mg/g for PE process) and shorter extraction time (1 h vs. ca . 12 h). Additionally, artemisinin in the PEG solution can be recovered using resin adsorber. The results show that the recovery of artemisinin could reach almost 100% by D101 or H103 porous resin, and then the drug could be desorbed from the resin by ethanol or ethyl acetate. Moreover, the kinetic and mechanism studies of the extraction process revealed that ultrasonic irradiation could enhance mass transfer and the hydrogen bonding interactions between artemisinin and PEG further facilitate the separation of artemisinin from the leaves. This work provides an alternative process for efficient artemisinin extraction by using an environmentally benign medium with outfield intensification, which could be potentially extended to the production of other natural drugs.
WOS关键词SUPERCRITICAL FLUIDS EXTRACTION ; POLYETHYLENE-GLYCOL ; IONIC LIQUIDS ; POLYSACCHARIDES ; SOLVENTS ; ETHANOL ; ACID ; WELL
资助项目National Natural Science Foundation of China[21878311] ; General Program Youth of National Natural Science Foundation of China[21603232] ; CAS Pioneer Hundred Talents Program ; K. C. Wong Education Foundation[GJTD-2018-04] ; Chinese Academy of Sciences (CAS) ; The World Academy of Sciences (TWAS)
WOS研究方向Engineering
语种英语
WOS记录号WOS:000489001800030
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; General Program Youth of National Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program ; K. C. Wong Education Foundation ; Chinese Academy of Sciences (CAS) ; The World Academy of Sciences (TWAS)
源URL[http://ir.ipe.ac.cn/handle/122111/31230]  
专题中国科学院过程工程研究所
通讯作者Wang, Hui
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing Key Lab Ion Liquids Clean Proc,CAS Key La, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Prawang, Phongphat,Zhang, Yongqiang,Zhang, Ying,et al. Ultrasonic Assisted Extraction of Artemisinin from Artemisia annua L. Using Poly(Ethylene Glycol): Toward a Greener Process[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,2019,58(2):18320-18328.
APA Prawang, Phongphat,Zhang, Yongqiang,Zhang, Ying,&Wang, Hui.(2019).Ultrasonic Assisted Extraction of Artemisinin from Artemisia annua L. Using Poly(Ethylene Glycol): Toward a Greener Process.INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,58(2),18320-18328.
MLA Prawang, Phongphat,et al."Ultrasonic Assisted Extraction of Artemisinin from Artemisia annua L. Using Poly(Ethylene Glycol): Toward a Greener Process".INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 58.2(2019):18320-18328.

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来源：过程工程研究所

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