Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy
文献类型：期刊论文
| 作者 | Sun, Xiao-Ying1,3; Dong, Quan-Xiu1,3; Zhu, Jie; Sun, Xun1,3; Zhang, Li-Fan3; Qiu, Mandy2; Yu, Xiao-Lin3; Liu, Rui-Tian3 |
| 刊名 | CURRENT ALZHEIMER RESEARCH
 |
| 出版日期 | 2019 |
| 卷号 | 16期号:8页码:710-722 |
| 关键词 | Resveratrol Alzheimer's disease tau oligomer neuroinflammation synapse loss |
| ISSN号 | 1567-2050 |
| DOI | 10.2174/1567205016666190801153751 |
| 英文摘要 | Alzheimer's Disease (AD) is characterized by the presence of extracellular amyloid-beta (A beta) plaques and intraneuronal neurofibrillary tangles assembled by the microtubule-associated protein tau. Increasing evidence demonstrated that tau pathology played an important role in AD progression. Resveratrol (RSV) has previously proved to exert neuroprotective effect against AD by inhibiting A beta generation and A beta-induced neurocytotoxicity, while its effect on tau pathology is still unknown. Methods: The effect of RSV on tau aggregation was measured by Thioflavin T fluorescence and Transmission electron microscope imaging. The effect of RSV on tau oligomer-induced cytotoxicity was assessed by MTT assay and the uptake of extracellular tau by N2a cells was determined by immunocytochemistry. 6-month-old male PS19 mice were treated with RSV or vehicle by oral administration (gayage) once a day for 5 weeks. The cognitive performance was determined using Morris water maze test, object recognition test and Y-maze test. The levels of phosphorylated-tau, gliosis, proinflammatory cytokines such as TNF-alpha and IL-beta, and synaptic proteins including synaptophysin and PSD95 in the brains of the mice were evaluated by immunoblotting, immunostaining and ELISA, respectively. Results: RSV significantly inhibited tau aggregation and tau oligomer-induced cytotoxicity, and blocked the uptake of extracellular tau oligomers by N2a cells. When applied to PS19 mice, RSV treatment effectively rescued cognitive deficits, reducing the levels of phosphorylated tau, neuroinflammation and synapse loss in the brains of mice. Conclusion: These findings suggest that RSV has promising therapeutic potential for AD and other tauopathies. |
| WOS关键词 | PAIRED HELICAL FILAMENTS ; ALZHEIMERS-DISEASE ; PROTEIN-TAU ; NEURODEGENERATION ; NEUROINFLAMMATION ; PATHOPHYSIOLOGY ; PHOSPHORYLATION ; OLIGOMERS ; TANGLES ; BETA |
| 资助项目 | National Science and Technology Major Projects of New Drugs[2018ZX09301032] ; National Science and Technology Major Projects of New Drugs[2018ZX09733001-001-008] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040215] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000489741300003 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 资助机构 | National Science and Technology Major Projects of New Drugs ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/31269]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Yu, Xiao-Lin; Liu, Rui-Tian |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Univ Auckland, Auckland 1023, New Zealand 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Xiao-Ying,Dong, Quan-Xiu,Zhu, Jie,et al. Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy[J]. CURRENT ALZHEIMER RESEARCH,2019,16(8):710-722. |
| APA | Sun, Xiao-Ying.,Dong, Quan-Xiu.,Zhu, Jie.,Sun, Xun.,Zhang, Li-Fan.,...&Liu, Rui-Tian.(2019).Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy.CURRENT ALZHEIMER RESEARCH,16(8),710-722. |
| MLA | Sun, Xiao-Ying,et al."Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy".CURRENT ALZHEIMER RESEARCH 16.8(2019):710-722. |
入库方式： OAI收割
来源：过程工程研究所
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