Imaging of water soluble CdTe/CdS core-shell quantum dots in inhibiting multidrug resistance of cancer cells
文献类型：期刊论文
| 作者 | Xu, Ning2; Piao, Mingxing1,2; Arkin, Kamile2; Ren, Lina2; Zhang, Jinyu2; Hao, Jiawei2; Zheng, Yuxin2; Shang, Qingkun2 |
| 刊名 | TALANTA
 |
| 出版日期 | 2019-08-15 |
| 卷号 | 201页码:309-316 |
| ISSN号 | 0039-9140 |
| 关键词 | Water-soluble core-shell quantum dots CdTe/CdS Fluorescent probe P-gp glycoprotein Cell imaging |
| DOI | 10.1016/j.talanta.2019.04.021 |
| 通讯作者 | Shang, Qingkun(shangqk995@nenu.edu.cn) |
| 英文摘要 | Two different colors of water-soluble core-shell quantum dots CdTe/CdS (green and orange red) have been synthesized and characterized in this paper. The formation of core-shell quantum dots not only improves the fluorescence quantum yield, but also reduces the biological toxicity of quantum dots, and improves the fluorescence lifetime. Two novel fluorescent bioprobes, CdTe/CdS (lambda(em) = 545 nm)-5-Fu and Bio-CdTe/CdS (lambda(em) = 600 nm)-TAM, have been synthesized via the interaction of these two core-shell quantum dots with anticancer drugs (5-Fu) and P-gp inhibitors (TAM), respectively. These two fluorescent probes have been simultaneously used in fluorescence imaging of human breast cancer cells MDA-MB-231/MDR. It can be observed that under the action of P-gp inhibitors distributed on the cell membrane, anticancer drugs can be retained in cancer cells. According to the color of quantum dots on the probe, the visualization results of the action of anticancer drugs and P-gp inhibitors can be obtained. This study shows that to prepare functional bioprobes using core-shell quantum dots CdTe/CdS has great potential in the field of biomedical research such as anticancer drugs. |
| 资助项目 | National Natural Science Foundation of China NSFC[21573039] ; National Natural Science Foundation of China NSFC[21872022] ; Jilin Province Science and Technology Development Project[20140414021GH] ; Jilin Province Personnel Department Project |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000471084300042 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/8215]  |
| 专题 | 微纳制造与系统集成研究中心 |
| 通讯作者 | Shang, Qingkun |
| 作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Key Lab Multiscale Mfg Technol, Chongqing 400714, Peoples R China 2.Northeast Normal Univ, Sch Chem, Changchun 130024, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Ning,Piao, Mingxing,Arkin, Kamile,et al. Imaging of water soluble CdTe/CdS core-shell quantum dots in inhibiting multidrug resistance of cancer cells[J]. TALANTA,2019,201:309-316. |
| APA | Xu, Ning.,Piao, Mingxing.,Arkin, Kamile.,Ren, Lina.,Zhang, Jinyu.,...&Shang, Qingkun.(2019).Imaging of water soluble CdTe/CdS core-shell quantum dots in inhibiting multidrug resistance of cancer cells.TALANTA,201,309-316. |
| MLA | Xu, Ning,et al."Imaging of water soluble CdTe/CdS core-shell quantum dots in inhibiting multidrug resistance of cancer cells".TALANTA 201(2019):309-316. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。