Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes
文献类型：期刊论文
| 作者 | Li L(李龙)5,6; Hu JL3,4 ; Rozycki B2; Song F(宋凡)1,5,6; Song F(宋凡); Li L(李龙); Li L(李龙)
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| 刊名 | NANO LETTERS
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| 出版日期 | 2020 |
| 卷号 | 20期号:1页码:722-728 |
| 关键词 | cell membrane adhesion receptor proteins nanoscale lipid clusters thermal fluctuations Monte Carlo simulations |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.9b04596 |
| 通讯作者 | Hu, Jinglei(hujinglei@nju.edu.cn) ; Rozycki, Bartosz(rozycki@ifpan.edu.pl) ; Song, Fan(songf@lnm.imech.ac.cn) |
| 英文摘要 | Nanoscale molecular clusters in cell membranes can serve as platforms to recruit membrane proteins for various biological functions. A central question is how these nanoclusters respond to physical contacts between cells. Using a statistical mechanics model and Monte Carlo simulations, we explore how the adhesion of cell membranes affects the stability and coalescence of clusters enriched in receptor proteins. Our results show that intercellular receptor ligand binding and membrane shape fluctuations can lead to receptor aggregation within the adhering membranes even if large-scale clusters are thermodynamically unstable in nonadhering membranes. |
| 分类号 | 一类 |
| WOS关键词 | LIPID RAFTS ; ANCHORED RECEPTORS ; MOLECULES ; ADHESION ; MYSTERY |
| 资助项目 | National Key Research and Development Program of China[2016YFA0501601] ; National Natural Science Foundation of China[21504038] ; National Natural Science Foundation of China[21973040] ; National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102] ; Opening Fund of State Key Laboratory of Nonlinear Mechanics ; National Science Centre, Poland[2016/21/B/NZ1/00006] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000507151600094 |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Opening Fund of State Key Laboratory of Nonlinear Mechanics ; National Science Centre, Poland |
| 其他责任者 | Hu, Jinglei ; Rozycki, Bartosz ; Song, Fan |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/81294]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 2.Polish Acad Sci, Inst Phys, Al Lotnikow 32-46, PL-02668 Warsaw, Poland; 3.Nanjing Univ, Inst Brain Sci, Nanjing 210023, Peoples R China; 4.Nanjing Univ, Kuang Yarning Honors Sch, Nanjing 210023, Peoples R China; 5.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; 6.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li L,Hu JL,Rozycki B,et al. Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes[J]. NANO LETTERS,2020,20(1):722-728. |
| APA | 李龙.,Hu JL.,Rozycki B.,宋凡.,Song F.,...&Li L.(2020).Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes.NANO LETTERS,20(1),722-728. |
| MLA | 李龙,et al."Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes".NANO LETTERS 20.1(2020):722-728. |
入库方式： OAI收割
来源：力学研究所
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