Enantiomorphic Microvortex-Enabled Supramolecular Sensing of Racemic Amino Acids by Using Achiral Building Blocks
文献类型：期刊论文
| 作者 | Li YK3,4; Liu C3,4; Bai X(白轩)1,3; Tian F3,4; Hu GQ(胡国庆)2; Sun JS3,4 ; Hu GQ(胡国庆)
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2020-01-24 |
| 页码 | 6 |
| 关键词 | chirality detection enantiomorphic microvortices racemic amino acids supramolecules |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201913882 |
| 通讯作者 | Sun, Jiashu(sunjs@nanoctr.cn) |
| 英文摘要 | Chiral analysis of bioactive molecules is of increasing significance in chemical and life sciences. However, the quantitative detection of a racemic mixture of enantiomers is a challenging task, which relies on complicated and time-consuming multiple steps of chiral derivatization, chiral separation, and spectroscopic measurement. Herein, we show that, without the use of chiral molecules or pretreatment steps, the co-assembly of amino acids with achiral TPPS4 monomers controlled by enantiomorphic microvortices allows quantitative detection of racemic or enantiomeric amino acids, through analysis of the sign and magnitude of supramolecular chirality in different outlets of a microfluidic platform. A model demonstrates that chiral microvortices can induce an initial chiral bias by bending the sheet structure, resulting in supramolecular self-assembly of TPPS4 and amino acids of compatible chirality by the self-sorting. This sensing system may find versatile applications in chiral sensing. |
| 分类号 | 一类 |
| WOS关键词 | HYDRODYNAMIC-FORCES ; CHIRALITY ; SELECTION ; VORTICES ; ORIGINS ; SYSTEMS ; ALANINE |
| 资助项目 | National Natural Science Foundation of China[21622503] ; National Natural Science Foundation of China[21904028] ; Chinese Academy of Sciences[YJKYYQ20180055] ; Chinese Academy of Sciences[ZDBS-LY-SLH025] ; Youth Innovation Promotion Association CAS[2016035] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000509299100001 |
| 资助机构 | National Natural Science Foundation of China ; Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS |
| 其他责任者 | Sun, Jiashu |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/81296]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China 2.Zhejiang Univ, Dept Engn Mech, Hangzhou 310027, Peoples R China; 3.Univ Chinese Acad Sci, Sch Future Technol, Beijing 100149, Peoples R China; 4.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li YK,Liu C,Bai X,et al. Enantiomorphic Microvortex-Enabled Supramolecular Sensing of Racemic Amino Acids by Using Achiral Building Blocks[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:6. |
| APA | Li YK.,Liu C.,白轩.,Tian F.,胡国庆.,...&Hu GQ.(2020).Enantiomorphic Microvortex-Enabled Supramolecular Sensing of Racemic Amino Acids by Using Achiral Building Blocks.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,6. |
| MLA | Li YK,et al."Enantiomorphic Microvortex-Enabled Supramolecular Sensing of Racemic Amino Acids by Using Achiral Building Blocks".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):6. |
入库方式： OAI收割
来源：力学研究所
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