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Is level of acetylation directly correlated to radiation sensitivity of cancer cell?

文献类型：期刊论文

作者Zhang, Fengqiu1,2,3; Chen, Zhu1,3; Shao, Changsheng1,3; Huang, Qing1,3
刊名MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
出版日期2019
卷号813页码:13-19
关键词Acetylation Radiosensitivity HeLa cells Histone deacetylase inhibitors (HDACis) Trichostatin A (TSA)
ISSN号0027-5107
DOI10.1016/j.mrfmmm.2018.11.001
通讯作者Huang, Qing(huangq@ipp.ac.cn)
英文摘要It is known that histone deacetylase inhibitors (HDACis) can modify acetylation of tumor cells and affect radiation sensitivity, or, radiosensitivity. While previous studies showed that trichostatin A (TSA, a typical HDACi) could enhance cell acetylation and so be used as radiation-sensitizer in radiotherapy, we questioned if the radiosensitivity is correlated with cellular acetylation directly. So we inspected radiation response of HeLa cells treated with TSA and investigated the time-dependent effect on radiosensitivity. To our surprise, HeLa cells treated with 200 nM TSA for shorter period (6 h) had relatively higher acetylation level but apparently less radiation damage compared to the irradiated cells with same radiation dose treatment of TSA but for longer time (24 h) with lower acetylation level, gainsaying the direct relationship between acetylation and radiosensitivity. We explained that the anti-oxidation activity for the combined treatments with TSA-radiation gave rise to the enhanced radiation protection of the cells at certain period of time. This work has therefore for the first time presented the experimental evidence showing that there is no direct relationship between acetylation and radiation sensitivity, and our results may also provide the guidance for optimized radiotherapy assisted by HDACis in cancer treatment.
WOS关键词HISTONE-DEACETYLASE INHIBITOR ; DNA-DAMAGE ; COMET-ASSAY ; GEL-ELECTROPHORESIS ; ANTIOXIDANT ENZYMES ; CARCINOMA-CELLS ; IN-VITRO ; TRICHOSTATIN ; RADIOSENSITIVITY ; EXPRESSION
资助项目National Natural Science Foundation of China[11635013] ; National Natural Science Foundation of China[11475217] ; National Natural Science Foundation of China[11704343] ; Key research Project of College of henan Province[18A180032]
WOS研究方向Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
语种英语
WOS记录号WOS:000455475900002
出版者ELSEVIER SCIENCE BV
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province ; Key research Project of College of henan Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/41331]  
专题合肥物质科学研究院_中科院强磁场科学中心
通讯作者Huang, Qing
作者单位1.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Inst Tech Biol & Agr Engn, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China
2.Zhengzhou Univ, Sch Phys Engn, Henan Key Lab Ion Beam Bioengn, Zhengzhou 450052, Henan, Peoples R China
3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Fengqiu,Chen, Zhu,Shao, Changsheng,et al. Is level of acetylation directly correlated to radiation sensitivity of cancer cell?[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,2019,813:13-19.
APA Zhang, Fengqiu,Chen, Zhu,Shao, Changsheng,&Huang, Qing.(2019).Is level of acetylation directly correlated to radiation sensitivity of cancer cell?.MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,813,13-19.
MLA Zhang, Fengqiu,et al."Is level of acetylation directly correlated to radiation sensitivity of cancer cell?".MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 813(2019):13-19.

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来源：合肥物质科学研究院

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