Activation of aryl hydrocarbon receptor by dioxin directly shifts gut microbiota in zebrafish
文献类型:期刊论文
作者 | Sun, Yumiao6; Tang, Lizhu6; Liu, Yang5; Hu, Chenyan4; Zhou, Bingsheng6; Lam, Paul K. S.2,3; Lam, James C. W.1,2,3; Chen, Lianguo6 |
刊名 | ENVIRONMENTAL POLLUTION |
出版日期 | 2019-12-01 |
卷号 | 255期号:1页码:12 |
ISSN号 | 0269-7491 |
关键词 | Gut microbiota Aryl hydrocarbon receptor PCB126 CH223191 Zebrafish intestinal health |
DOI | 10.1016/j.envpol.2019.113357 |
英文摘要 | Gut microbiota is of critical importance to host health. Aryl hydrocarbon receptor (AhR) is found to be closely involved in the regulation of gut microbial dynamics. However, it is still not clear how AhR signaling shapes the gut microbiota. In the present study, adult zebrafish were acutely exposed to an AhR antagonist (CH223191), an AhR agonist (polychlorinated biphenyl 126; PCB126) or their combination for 7 d. Overall intestinal health and gut microbial community were temporally monitored (1 d, 3 d and 7 d) and inter-compared among different groups. The results showed that single exposure to PCB126 significantly disrupted the overall health of intestines (i.e., neural signaling, inflammation, epithelial barrier integrity, oxidative stress). However, CH223191 failed to inhibit but enhanced the physiological toxicities of PCB126, implying the involvement of extra mechanisms rather than AhR in the regulation of intestinal physiological activities. Dysbiosis of gut microbiota was also caused by PCB126 over time as a function of sex. It is intriguing that CH223191 successfully abolished the holistic effects of dioxin on gut microbiota, which inferred that growth of gut microbes was directly controlled by AhR activation without the involvement of host feedback modulation. When coming to detailed alterations at certain taxon, both antagonistic and synergistic interactions existed between CH223191 and dioxin, depending on fish sex, exposure duration and bacterial species. Correlation analysis found that gut inflammation was positively associated with pathogenic Legionella bacteria, but was negatively associated with epithelial barrier integrity, suggesting that integral intestinal epithelial barrier can prevent the influx of pathogenic bacteria to induce inflammatory response. Overall, this study has deciphered, for the first time, the direct regulative effects of AhR activity on gut microbiota. Future research is warranted to elucidate the specific mechanisms of AhR action on certain bacterial population. (C) 2019 Elsevier Ltd. All rights reserved. |
WOS关键词 | ENVIRONMENTAL-POLLUTANTS ; ESTROGEN-RECEPTOR ; GENE-EXPRESSION ; HEALTH ; EXPOSURE ; OBESITY ; PBDES ; ALPHA |
资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDB14040103] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03] |
WOS研究方向 | Environmental Sciences & Ecology |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000498321100012 |
资助机构 | Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; 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源URL | [http://ir.ihb.ac.cn/handle/342005/34881] |
专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
通讯作者 | Chen, Lianguo |
作者单位 | 1.Educ Univ Hong Kong, Dept Sci & Environm Studies, Tai Po, 10 Lo Ping Rd, Hong Kong, Peoples R China 2.City Univ Hong Kong, Dept Chem, Kowloon, Hong Kong, Peoples R China 3.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China 4.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Hubei, Peoples R China 5.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China 6.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Yumiao,Tang, Lizhu,Liu, Yang,et al. Activation of aryl hydrocarbon receptor by dioxin directly shifts gut microbiota in zebrafish[J]. ENVIRONMENTAL POLLUTION,2019,255(1):12. |
APA | Sun, Yumiao.,Tang, Lizhu.,Liu, Yang.,Hu, Chenyan.,Zhou, Bingsheng.,...&Chen, Lianguo.(2019).Activation of aryl hydrocarbon receptor by dioxin directly shifts gut microbiota in zebrafish.ENVIRONMENTAL POLLUTION,255(1),12. |
MLA | Sun, Yumiao,et al."Activation of aryl hydrocarbon receptor by dioxin directly shifts gut microbiota in zebrafish".ENVIRONMENTAL POLLUTION 255.1(2019):12. |
入库方式: OAI收割
来源:水生生物研究所
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