Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish
文献类型:期刊论文
作者 | Luo, Jing2; Zhang, Xiaokang2; He, Siying2; Lou, Qiyong1; Zhai, Gang1; Shi, Chuang1; Yin, Zhan1; Zheng, Fang2 |
刊名 | REDOX BIOLOGY |
出版日期 | 2020 |
卷号 | 28期号:1页码:8 |
ISSN号 | 2213-2317 |
关键词 | Narfl Oxidative stress Angiogenesis Zebrafish |
DOI | 10.1016/j.redox.2019.101355 |
英文摘要 | Nuclear prelamin A recognition factor-like (NARFL) is a human protein that participates in cytosolic iron-sulfur (FeS) protein biogenesis and cellular defense against oxidative stress. Previous studies of Narfl knockout mice did not reveal well the regulatory mechanisms of embryonic development mediated by Narfl because the homozygous mice die in utero. Here, we investigated the function of narfl in an established zebrafish knockout model by taking advantage of zebrafish external fertilization and ease of embryonic development examination. Our experiments showed that narfl deletion resulted in larvae lethality, subintestinal vessel (SIV) malformation and digestive organ defects in the early stages of embryonic development. Biochemical analyses and western blot revealed increased oxidative stress and upregulated hypoxia-inducible factor-1 alpha (HIF-1 alpha) expression in narfl(-/-) fish. The use of HIF-1 alpha inhibitor 2-methoxyestradiol (2ME2) for the treatment of mutants partially rescued the SIV sprouting. These results suggest that narfl deletion causes increased oxidative stress and subintestinal vessel malformation, which further influence the development of digestive organs and might contribute to the lethality of the narfl knockout fish. |
WOS关键词 | INDUCIBLE FACTOR 1-ALPHA ; PATHWAY ; HIF-1-ALPHA ; BIOGENESIS ; PROTEIN ; GROWTH ; IOP1 |
资助项目 | National Natural Science Foundation of China[81472024] ; National Natural Science Foundation of China[81871722] |
WOS研究方向 | Biochemistry & Molecular Biology |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000501490700026 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
源URL | [http://ir.ihb.ac.cn/handle/342005/34921] |
专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
通讯作者 | Yin, Zhan; Zheng, Fang |
作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 2.Wuhan Univ, Zhongnan Hosp, Ctr Gene Diag, Wuhan 430071, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Luo, Jing,Zhang, Xiaokang,He, Siying,et al. Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish[J]. REDOX BIOLOGY,2020,28(1):8. |
APA | Luo, Jing.,Zhang, Xiaokang.,He, Siying.,Lou, Qiyong.,Zhai, Gang.,...&Zheng, Fang.(2020).Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish.REDOX BIOLOGY,28(1),8. |
MLA | Luo, Jing,et al."Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish".REDOX BIOLOGY 28.1(2020):8. |
入库方式: OAI收割
来源:水生生物研究所
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。