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Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish

文献类型：期刊论文

作者Zhang, Chang3,4,5; Zhang, Qin3,4,5; Wang, Junya3,4,5; Tian, Jiayin3,4,5; Song, Yunjie3,4,5; Xie, Haixia2; Chang, Mingxian2; Nie, Pin2; Gao, Qian3,4,5; Zou, Jun1,3,4,5
刊名FISH & SHELLFISH IMMUNOLOGY
出版日期2019-11-01
卷号94页码:685-696
ISSN号1050-4648
关键词S100 family Gene expression Bacterial and viral infection Zebrafish
DOI10.1016/j.fsi.2019.09.051
通讯作者Gao, Qian(qgao@shou.edu.cn) ; Zou, Jun(jzou@shou.edu.cn)
英文摘要The S100 family proteins are a group of small acidic polypeptides and have diverse functions in regulating many aspects of physiological processes. They are structurally conserved and possess two EF-hands which are central for calcium-mediated functions. In this study, 14 S100 cDNA sequences were determined in zebrafish and their genomic organizations confirmed. Re-analyzing the gene synteny of the S100 loci identified two major S100 loci in Chr16 and Chr19 which share remarkable conservation with the S100 locus in human Chri, suggesting they may have evolved from a single locus during the teleost specific whole genome duplication event. It appears that the homologues of human S100G and SlOOP have been lost in zebrafish. Expression analysis reveals that S100W, ICN1 and ICN2 are markedly expressed in embryos. Further, the transcripts of S100 genes are relatively abundant in mucosal tissues such as gills and gut. Intraperitoneal injection of poly(I:C) resulted in up-regulation of most S100 genes in the gut and spleen, with highest induction of S100V2 and S100Z detected. In fish challenged with spring viremia of carp virus (SVCV), expression of most S100 family genes was increased in the spleen between day 1 and 7 post infection, with consistent induction seen for the S100A1, S100A10b, S100B, S100ICN1, S100T, S100U, S100V1 and S100Z. Interestingly, intraperitoneal injection of Edwardsiella tardy down-regulated S100 expression in the gut but resulted in induction in the spleen. The results demonstrate that the S100 family genes are differentially modulated by bacterial and viral pathogens in zebrafish.
WOS关键词CALCIUM-BINDING PROTEINS ; EPIDERMAL DIFFERENTIATION ; SKIN
资助项目National Key R&D Program of China[2018YFD0900302] ; National Natural Science Foundation of China[U1605211] ; National Natural Science Foundation of China[31272666] ; State Key Laboratory of Freshwater Ecology and Biotechnology of China[Y119011F01]
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号WOS:000496892400072
资助机构National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China ; State Key Laboratory of Freshwater Ecology and Biotechnology of China
源URL[http://ir.ihb.ac.cn/handle/342005/34800]  
专题水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
通讯作者Gao, Qian; Zou, Jun
作者单位1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
3.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai, Peoples R China
4.Shanghai Ocean Univ, Minist Sci & Technol, Int Res Ctr Marine Biosci, Shanghai, Peoples R China
5.Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Chang,Zhang, Qin,Wang, Junya,et al. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish[J]. FISH & SHELLFISH IMMUNOLOGY,2019,94:685-696.
APA Zhang, Chang.,Zhang, Qin.,Wang, Junya.,Tian, Jiayin.,Song, Yunjie.,...&Zou, Jun.(2019).Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish.FISH & SHELLFISH IMMUNOLOGY,94,685-696.
MLA Zhang, Chang,et al."Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish".FISH & SHELLFISH IMMUNOLOGY 94(2019):685-696.

入库方式： OAI收割

来源：水生生物研究所

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