Construction of a high-density genetic linkage map and mapping of quantitative trait loci for growth-related traits in silver carp (Hypophthalmichthys molitrix)
文献类型：期刊论文
| 作者 | Wang, Xinhua2,3; Liu, Haiyang2; Pang, Meixia2; Fu, Beide2; Yu, Xiaomu2; He, Shunping1; Tong, Jingou2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2019-11-25 |
| 卷号 | 9页码:12 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-019-53469-8 |
| 通讯作者 | Tong, Jingou(jgtong@ihb.ac.cn) |
| 英文摘要 | High-density genetic map and quantitative trait loci (QTL) mapping are powerful tools for identifying genomic regions that may be responsible for such polygenic trait as growth. A high-density genetic linkage map was constructed by sequencing 198 individuals in a F-1 family of silver carp (Hypophthalmichthys molitrix) in this study. This genetic map spans a length of 2,721.07 cM with 3,134 SNPs distributed on 24 linkage groups (LGs). Comparative genomic mapping presented a high level of syntenic relationship between silver carp and zebrafish. We detected one major and nineteen suggestive QTL for 4 growth-related traits (body length, body height, head length and body weight) at 6, 12 and 18 months post hatch (mph), explaining 10.2 similar to 19.5% of phenotypic variation. All six QTL for growth traits of 12 mph generally overlapped with QTL for 6 mph, while the majority of QTL for 18 mph were identified on two additional LGs, which may reveal a different genetic modulation during early and late muscle growth stages. Four potential candidate genes were identified from the QTL regions by homology searching of marker sequences against zebrafish genome. Hepcidin, a potential candidate gene identified from a QTL interval on LG16, was significantly associated with growth traits in the analyses of both phenotype-SNP association and mRNA expression between small-size and large-size groups of silver carp. These results provide a basis for elucidating the genetic mechanisms for growth and body formation in silver carp, a world aquaculture fish. |
| WOS关键词 | PROVIDES INSIGHTS ; PEARL OYSTER ; BODY-WEIGHT ; GENOME ; QTL ; FISHES ; EXPRESSION ; DISTORTION ; EVOLUTION ; 2B-RAD |
| 资助项目 | National Key R & D Program of China[2018YFD0900102] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ04] ; Natural Science Foundation of China[3127247] ; Natural Science Foundation of China[31472268] ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy[53000181] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000498515100001 |
| 资助机构 | National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy ; PhD Scientific Research Startup Foundation of Henan University of Animal Husbandry and Economy |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/34822]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 通讯作者 | Tong, Jingou |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat CAS, Wuhan 430072, Hubei, Peoples R China 2.Chinese Acad Sci, Innovat Acad Seed Design, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 3.Henan Univ Anim Husb & Econ, Coll Anim Sci & Technol, Zhengzhou 450046, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xinhua,Liu, Haiyang,Pang, Meixia,et al. Construction of a high-density genetic linkage map and mapping of quantitative trait loci for growth-related traits in silver carp (Hypophthalmichthys molitrix)[J]. SCIENTIFIC REPORTS,2019,9:12. |
| APA | Wang, Xinhua.,Liu, Haiyang.,Pang, Meixia.,Fu, Beide.,Yu, Xiaomu.,...&Tong, Jingou.(2019).Construction of a high-density genetic linkage map and mapping of quantitative trait loci for growth-related traits in silver carp (Hypophthalmichthys molitrix).SCIENTIFIC REPORTS,9,12. |
| MLA | Wang, Xinhua,et al."Construction of a high-density genetic linkage map and mapping of quantitative trait loci for growth-related traits in silver carp (Hypophthalmichthys molitrix)".SCIENTIFIC REPORTS 9(2019):12. |
入库方式： OAI收割
来源：水生生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。