中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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  1. CAS IR Grid
  2. 水生生物研究所
  3. 鱼类生物学及渔业生物技术研究中心
  4. 期刊论文
Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival

文献类型：期刊论文

作者Chen, MingYue2; Luo, Yi2; Xu, JiangPing2; Chang, Ming-Xian1; Liu, Jing-Xia2
刊名FRONTIERS IN IMMUNOLOGY
出版日期2019-11-08
卷号10期号:1页码:16
关键词copper macrophages and neutrophils phagocytosis mROS apoptosis immune responses
ISSN号1664-3224
DOI10.3389/fimmu.2019.02599
英文摘要

Copper has been revealed to negatively affect the hematopoietic system, which has an important function in immune pathogen defense, but little is known about the potential mechanism. In this study, copper-stressed larvae exhibited significantly increased mortality as well as reduced percentages of GFP-labeled macrophages and neutrophils after Aeromonas hydrophila (A. hydrophila) infection. However, those copper-stressed GFP-labeled macrophages and neutrophils showed more rapid responses to A. hydrophila infection. The transcriptional profiles in copper-stressed macrophages or neutrophils were unveiled by RNA-Sequencing, and KEGG pathway analysis revealed enrichment of differentially expressed genes (DEGs) in lysosome, apoptosis, oxidative phosphorylation, phagosome, etc. The copper-stressed macrophages or neutrophils were revealed to have an increase in reactive oxygen species (ROS) and mitochondria ROS (mROS)-mediated apoptosis, and a reduction in phagocytosis. Furthermore, the A. hydrophila-infected copper-stressed macrophages or neutrophils were found to be unable to maintain a consistently increased expression in immune responsive genes. This study demonstrated for the first time that copper might induce the susceptibility of fish larvae to inflammatory stimuli via triggering macrophage or neutrophil apoptosis, leading to reduced phagocytic activities and non-sustainable immune responses in immune macrophages or neutrophils.

WOS关键词TRANSCRIPTOME ANALYSIS ; BACTERICIDAL ACTIVITY ; OXIDATIVE STRESS ; CELLS ; MACROPHAGES ; BEHAVIOR ; NEUTROPHILS ; ACTIVATION ; MECHANISMS ; EXPRESSION
资助项目National Key R&D Program of China[2018YFD0900101] ; Fundamental Research Funds for the Central University[2662018JC024] ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms
WOS研究方向Immunology
语种英语
WOS记录号WOS:000501014200001
出版者FRONTIERS MEDIA SA
资助机构National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; 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Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; 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project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; 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Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms ; project of Key Laboratory of Biodiversity and Conservation of Aquatic Organisms
源URL[http://ir.ihb.ac.cn/handle/342005/34890]  
专题水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
通讯作者Liu, Jing-Xia
作者单位1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China
2.Huazhong Agr Univ, Coll Fisheries, Key Lab Freshwater Anim Breeding, Minist Agr, Wuhan, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Chen, MingYue,Luo, Yi,Xu, JiangPing,et al. Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival[J]. FRONTIERS IN IMMUNOLOGY,2019,10(1):16.
APA Chen, MingYue,Luo, Yi,Xu, JiangPing,Chang, Ming-Xian,&Liu, Jing-Xia.(2019).Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival.FRONTIERS IN IMMUNOLOGY,10(1),16.
MLA Chen, MingYue,et al."Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival".FRONTIERS IN IMMUNOLOGY 10.1(2019):16.

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来源：水生生物研究所

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