beta-glucan mitigated trinitrobenzene sulfonic acid-induced enteritis in the rainbow trout (Oncorhynchus mykiss)
文献类型：期刊论文
| 作者 | Ji, Liqin3,4,5; Fu, Songzhe1; Ji, Renlei2; Li, Xian4,5; Liu, Ying1,4
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| 刊名 | AQUACULTURE
 |
| 出版日期 | 2019-11-15 |
| 卷号 | 513页码:9 |
| 关键词 | beta-glucan TNBS Enteritis Rainbow trout |
| ISSN号 | 0044-8486 |
| DOI | 10.1016/j.aquaculture.2019.734393 |
| 通讯作者 | Liu, Ying(yingliu@dlou.edu.cn) |
| 英文摘要 | Enteritis is a common disease in fish which can be induced by a variety of factors. To study the effects of beta-glucan on enteritis of rainbow trout (Oncorhynchus mykiss), fish were administrated different beta-glucan levels (0, 0.1%, and 0.2%) for 30 days. Then individuals in all groups had enteritis induced with Trinitrobenzene Sulfonic Acid (TNBS) (75 mg per kg of body weight) and were sampled on 3, 6, and 9 days post inflammation (dpi). The growth data showed that 0.2% beta-glucan significantly improved the weight gain, specific growth rate, and feed efficiency (p < .05). The enteritis-induced weight loss percentage was largest on 6 dpi in all groups which was attenuated in the 0.2% beta-glucan group (BG) (p < .05). In addition, 0.1% and 0.2% beta-glucan dose-dependently decreased cumulative mortality rate during enteritis (p < .05). The intestinal histology and related scores of pathomorphological changes indicated that lesions of intestinal structure appeared on 3 dpi and became more severe on 6 dpi in all groups. Comparatively, intestinal lesions were the mildest in the 0.2% BG (p < .05). The changes of white blood cells, red blood cells, and hemoglobin in the 0.1% and 0.2% BG were smaller than in the control group post enteritis (p < .05). Besides that, enteritis increased serum antioxidant activities consisting of SOD, CAT, GSH, GSH-Px, MPO, and T-AOC. However, these increases were weakened in the 0.2% BG (p < .05). Lastly, 0.2% beta-glucan alleviated mRNA up-regulation of pro-inflammatory cytokines including il-1 beta, i1-6, and tnf-alpha in distal intestine, in contrast, it enhanced the mRNA up-regulation of anti-inflammatory cytokine il-10 and host defense peptides including cath-1 and cath-2 < .05). To sum up, this is the first study to induce enteritis with TNBS in rainbow trout. Besides that, 0.1% and 0.2% beta-glucan could dose-dependently mitigate TNBS-induced enteritis in rainbow trout. This research provides the evidence to support beta-glucan as a therapeutic or protective substance in commercial fish enteritis. |
| 资助项目 | National Key Technologies RD Program[2017YFB0404000] ; Key Technologies R&D Program of Shandong Province[2018GHY115031] |
| WOS研究方向 | Fisheries ; Marine & Freshwater Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000497647200011 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/163753]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Liu, Ying |
| 作者单位 | 1.Dalian Ocean Univ, Sch Marine Sci & Environm Engn, 52 Heroitte St, Dalian 116023, Peoples R China 2.Auburn Univ, Coll Vet Med, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266235, Shandong, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Liqin,Fu, Songzhe,Ji, Renlei,et al. beta-glucan mitigated trinitrobenzene sulfonic acid-induced enteritis in the rainbow trout (Oncorhynchus mykiss)[J]. AQUACULTURE,2019,513:9. |
| APA | Ji, Liqin,Fu, Songzhe,Ji, Renlei,Li, Xian,&Liu, Ying.(2019).beta-glucan mitigated trinitrobenzene sulfonic acid-induced enteritis in the rainbow trout (Oncorhynchus mykiss).AQUACULTURE,513,9. |
| MLA | Ji, Liqin,et al."beta-glucan mitigated trinitrobenzene sulfonic acid-induced enteritis in the rainbow trout (Oncorhynchus mykiss)".AQUACULTURE 513(2019):9. |
入库方式： OAI收割
来源：海洋研究所
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