中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 海洋研究所
  3. 中国科学院海洋研究所
  4. 实验海洋生物学重点实验室
Highly oxygenated polyketides produced by Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the fresh roots of the medicinal plant Artemisia argyi

文献类型：期刊论文

作者Shi, Xiao-Shan1,2,4,5; Li, Hong-Lei1,2,3,4; Li, Xiao-Ming1,2,3,4; Wang, Dun-Jia5; Li, Xin1,2,3,4; Meng, Ling-Hong1,2,3,4; Zhou, Xing-Wang5; Wang, Bin-Gui1,2,3,4
刊名BIOORGANIC CHEMISTRY
出版日期2020
卷号94页码:9
关键词Artemisia argyi Endophytic fungus Trichoderma koningiopsis Secondary metabolites Polyketides Antimicrobial activities
ISSN号0045-2068
DOI10.1016/j.bioorg.2019.103448
通讯作者Zhou, Xing-Wang(zhouxw@hbnu.edu.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
英文摘要Eight new highly oxygenated fungal polyketides, namely, 15-hydroxy-1,4,5,6-tetra-epi-koninginin G (1), 14-hydroxykoninginin E (2), koninginin U (3), 4'-hydroxykoninginin U (4), koninginin V (5), 14-ketokoninginin B (6), 14-hydroxykoninginin B (7), and 7-O-methylkoninginin B (8), together with six known related analogues (9-14), were isolated from Trichoderma koningiopsis QA-3, a fungus obtained from the inner root tissue of the well known medicinal plant Artemisia argyi. All these compounds are bicyclic polyketides, with compound 1 contains unusual hemiketal moiety at C-5 and compounds 2-14 having ketone group at C-1 and double bond at C-5(6). The structures and absolute configurations of the new compounds were established by spectroscopic analysis, X-ray crystal diffraction, modified Mosher's method, and ECD calculation. The absolute configurations of the known compounds 9, 10, and 12 were determined by X-ray crystal diffractions for the first time. The antimicrobial activities against human pathogen, marine-derived aquatic bacteria, and plant-pathogenic fungi of compounds 1-14 were evaluated, and compound 1 showed remarkable activity against aquatic pathogen Vibrio alginolyticus with MIC value 1 mu g/mL, which is as active as that of the positive control.
资助项目National Natural Science Foundation of China[31870328] ; Taishan Scholar Program from Shandong Province of China[ts201511060]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000505596300100
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://ir.qdio.ac.cn/handle/337002/164367]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Zhou, Xing-Wang; Wang, Bin-Gui
作者单位1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
5.Hubei Normal Univ, Coll Chem & Chem Engn, Cihu Rd 11, Huangshi 435002, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Shi, Xiao-Shan,Li, Hong-Lei,Li, Xiao-Ming,et al. Highly oxygenated polyketides produced by Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the fresh roots of the medicinal plant Artemisia argyi[J]. BIOORGANIC CHEMISTRY,2020,94:9.
APA Shi, Xiao-Shan.,Li, Hong-Lei.,Li, Xiao-Ming.,Wang, Dun-Jia.,Li, Xin.,...&Wang, Bin-Gui.(2020).Highly oxygenated polyketides produced by Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the fresh roots of the medicinal plant Artemisia argyi.BIOORGANIC CHEMISTRY,94,9.
MLA Shi, Xiao-Shan,et al."Highly oxygenated polyketides produced by Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the fresh roots of the medicinal plant Artemisia argyi".BIOORGANIC CHEMISTRY 94(2020):9.

入库方式： OAI收割

来源：海洋研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。